| + |
CAMK2B | down-regulates activity 
phosphorylation
|
ETS1 |
0.302 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250684 |
Ser251 |
GKLGGQDsFESIESY |
|
DG-75 Cell |
| pmid |
sentence |
| 12475968 |
Increased Transactivation of the GM-CSF Promoter/Enhancer by Ets1 with Mutated CaMK II Sites | Significantly, phosphorylation of Ets1 by Ca2+-dependent pathways is thought to inhibit DNA binding in vitro. To analyze the role of these four serines, S251, S257, S282, and S285, in transcription, we constructed three mutant derivatives of human Ets1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250685 |
Ser257 |
DSFESIEsYDSCDRL |
|
DG-75 Cell |
| pmid |
sentence |
| 12475968 |
Increased Transactivation of the GM-CSF Promoter/Enhancer by Ets1 with Mutated CaMK II Sites | Significantly, phosphorylation of Ets1 by Ca2+-dependent pathways is thought to inhibit DNA binding in vitro. To analyze the role of these four serines, S251, S257, S282, and S285, in transcription, we constructed three mutant derivatives of human Ets1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250686 |
Ser282 |
NSLQRVPsYDSFDSE |
|
DG-75 Cell |
| pmid |
sentence |
| 12475968 |
Increased Transactivation of the GM-CSF Promoter/Enhancer by Ets1 with Mutated CaMK II Sites | Significantly, phosphorylation of Ets1 by Ca2+-dependent pathways is thought to inhibit DNA binding in vitro. To analyze the role of these four serines, S251, S257, S282, and S285, in transcription, we constructed three mutant derivatives of human Ets1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250687 |
Ser285 |
QRVPSYDsFDSEDYP |
|
DG-75 Cell |
| pmid |
sentence |
| 12475968 |
Increased Transactivation of the GM-CSF Promoter/Enhancer by Ets1 with Mutated CaMK II Sites | Significantly, phosphorylation of Ets1 by Ca2+-dependent pathways is thought to inhibit DNA binding in vitro. To analyze the role of these four serines, S251, S257, S282, and S285, in transcription, we constructed three mutant derivatives of human Ets1 |
|
| Publications: |
4 |
| + |
CAMK2A | down-regulates
phosphorylation
|
ETS1 |
0.302 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-96330 |
Ser251 |
GKLGGQDsFESIESY |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 12475968 |
Treatment of ets1 by t-cell nuclear extract or phosphorylation of these four serines by calmodulin-dependent kinase ii (camk ii) has recently been reported to decrease ets1 dna binding by reinforcing autoinhibition |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-96334 |
Ser257 |
DSFESIEsYDSCDRL |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 12475968 |
Treatment of ets1 by t-cell nuclear extract or phosphorylation of these four serines by calmodulin-dependent kinase ii (camk ii) has recently been reported to decrease ets1 dna binding by reinforcing autoinhibition |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-96338 |
Ser282 |
NSLQRVPsYDSFDSE |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 12475968 |
Treatment of ets1 by t-cell nuclear extract or phosphorylation of these four serines by calmodulin-dependent kinase ii (camk ii) has recently been reported to decrease ets1 dna binding by reinforcing autoinhibition |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-96342 |
Ser285 |
QRVPSYDsFDSEDYP |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 12475968 |
Treatment of ets1 by t-cell nuclear extract or phosphorylation of these four serines by calmodulin-dependent kinase ii (camk ii) has recently been reported to decrease ets1 dna binding by reinforcing autoinhibition |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
GSK3B | up-regulates quantity by stabilization 
phosphorylation
|
ETS1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277561 |
Ser269 |
DRLTQSWsSQSSFNS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 34023818 |
Here, we show that ETS1 forms a complex with glycogen synthase kinase-3β (GSK3β). Specifically, GSK3β-mediated phosphorylation of ETS1 at threonine 265 and serine 269 promoted protein stability, induced the transcriptional activation of matrix metalloproteinase (MMP)-9, and increased cell migration. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277560 |
Thr265 |
YDSCDRLtQSWSSQS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 34023818 |
Here, we show that ETS1 forms a complex with glycogen synthase kinase-3β (GSK3β). Specifically, GSK3β-mediated phosphorylation of ETS1 at threonine 265 and serine 269 promoted protein stability, induced the transcriptional activation of matrix metalloproteinase (MMP)-9, and increased cell migration. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK3 | up-regulates
phosphorylation
|
ETS1 |
0.685 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-116494 |
Thr38 |
CADVPLLtPSSKEMM |
Homo sapiens |
|
| pmid |
sentence |
| 11948414 |
We found that hgf/sf activates the erk1 map kinase, leading to the phosphorylation of the threonine 38 residue of ets1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK7 | up-regulates
phosphorylation
|
ETS1 |
0.411 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-88666 |
Thr38 |
CADVPLLtPSSKEMM |
Homo sapiens |
|
| pmid |
sentence |
| 12048211 |
9-cis retinoid x receptor alpha (rxr alpha) interacted with erk2 but not erk5 in intact cells, whereas ets-1 interacted preferentially with erk5. Increased phosphorylation of rxr alpha and ets-1 was detected in response to 1,25d. Activated erk2 and erk5 specifically phosphorylated rxr alpha and ets-1, respectively.Mutagenesis of ets-1 (t38a) reduced cyp24 promoter activity to levels observed with the dominant-negative mek5(a) and inhibited erk5-directed phosphorylation. Mutated rxr alpha (s260a) inhibited 1,25d-induced cyp24 promoter activity and abolished phosphorylation by activated erk2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ETS1 | up-regulates quantity by expression
transcriptional regulation
|
TBX22 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265565 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 25373698 |
TBX22 is an X-linked gene, which encodes a T-box-containing transcription factor. Loss-of-function mutation in the X-linked TBX22 promoter disrupts an ETS-1 binding site and leads to cleft palate. We first link the transcription factor ETS-1 to TBX22 pathway during embryonic palatogenesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TLX3 | down-regulates activity
binding
|
ETS1 |
0.356 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259098 |
|
|
Homo sapiens |
T-lymphoblastic Leukemia Cell Line |
| pmid |
sentence |
| 22516263 |
We show that the cortical thymic maturation arrest in T-lineage ALLs that overexpress TLX1 or TLX3 is due to binding of TLX1/TLX3 to ETS1, leading to repression of T cell receptor (TCR) α enhanceosome activity and blocked TCR-Jα rearrangement. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ETS1 | up-regulates 
|
Apoptosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259869 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11175361 |
Ets1 and Ets2 seem to play opposing roles in apoptosis. While Ets1 seems to activate pro-apoptotic pathways, Ets2 seems to inhibit apoptosis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ETS1 | up-regulates quantity by expression
transcriptional regulation
|
SLC26A3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254085 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 7935445 |
Ets-1 activates the DRA promoter in B cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ETS1 | up-regulates quantity by expression
transcriptional regulation
|
TBXAS1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254088 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14586398 |
We demonstrate that p53 and ets-1 coregulate TXSA in an antagonistic and inter-related manner, with ets-1 being a potent transcriptional activator and p53 inhibiting ets-1-dependent transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ETS1 | up-regulates quantity by expression
transcriptional regulation
|
MUC4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254098 |
|
|
Homo sapiens |
BxPC-3 Cell |
| pmid |
sentence |
| 19757157 |
Through promoter screening, overexpressing methods and luciferase reporter studies, we found that transcription factors CREB, Ets-1, Elk-1 and STAT1 can positively regulate MUC4 expression at the promoter and mRNA level. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ETS1 | up-regulates quantity by expression
transcriptional regulation
|
CD8A |
0.255 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254078 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8413295 |
Taken together, these results suggest that the human CD8 alpha gene is regulated by the interaction of multiple T-cell nuclear proteins with a transcriptional enhancer located in the last intron of the gene. Site-directed mutation of the Ets-1 and GATA-3 sites dramatically reduced enhancer activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ETS1 | up-regulates quantity
transcriptional regulation
|
FOS |
0.731 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256495 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1722028 |
Furthermore, the possible involvement of an Ets protein in the control of c-fos has interesting implications for proto-oncogene cooperation in cellular growth control. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ETS1 | down-regulates activity
binding
|
GFI1 |
0.418 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254202 |
|
|
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 17213822 |
Co-immunoprecipitation analyses and glutathione-S-transferase pull-down assays revealed that ETS1 bound directly to GFI1 via its Ets domain, and GFI1 bound to ETS1 via its zinc-finger domain. Luciferase (Luc) assays using artificial reporters showed that GFI1 repressed ETS1-mediated transcriptional activation and ETS1 repressed GFI1-mediated transcriptional activation, in a dose-dependent manner. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAF | down-regulates
binding
|
ETS1 |
0.416 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-56808 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9566892 |
Full-length c-maf binds to the c-myb and ets-1. / c-maf inhibits c-myb and ets-1 transcriptional activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ETS1 | up-regulates quantity by expression
transcriptional regulation
|
GP6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254082 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12377757 |
We have determined that the GP6 sequence -191 to -39 represents the core promoter and that transcription is driven largely by GATA-1 (-176) and c-Ets-1 (-45) sites within this segment. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ETS1 | up-regulates quantity by expression
transcriptional regulation
|
MMP9 |
0.374 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254083 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22270366 |
VEGF-induced MMP-9 and MMP-13 promoter activities were down-regulated in ETS-1 siRNA-transfected cells. it is hypothesized that the activation of PI3K/AKT and p38 MAPK by VEGF results in ETS-1 gene expression, which activates MMP-9 and MMP-13, leading to the invasion and scattering of SKOV-3 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GFI1 | down-regulates activity
binding
|
ETS1 |
0.418 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254201 |
|
|
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 17213822 |
Co-immunoprecipitation analyses and glutathione-S-transferase pull-down assays revealed that ETS1 bound directly to GFI1 via its Ets domain, and GFI1 bound to ETS1 via its zinc-finger domain. Luciferase (Luc) assays using artificial reporters showed that GFI1 repressed ETS1-mediated transcriptional activation and ETS1 repressed GFI1-mediated transcriptional activation, in a dose-dependent manner. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ETS1 | up-regulates quantity by expression
transcriptional regulation
|
VWF |
0.292 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253915 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9444957 |
Cotransfection of Ets-1 and Erg expression plasmids is sufficient to induce the -60/+19 vWF promoter activity in HeLa cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ETS1 | up-regulates quantity by expression
transcriptional regulation
|
ABCB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254077 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20392592 |
High ETS1 expression levels in all resistant MCF-7 sublines may lead to the upregulation of the transcription of MDR1 gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ETS1 | up-regulates quantity by expression
transcriptional regulation
|
ECE1 |
0.261 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254080 |
|
|
Homo sapiens |
EAhy 926 Cell |
| pmid |
sentence |
| 9595399 |
Endothelial expression of endothelin-converting enzyme-1 beta mRNA is regulated by the transcription factor Ets-1. We conclude that Ets-1 is involved in transcriptional upregulation of ECE-1 beta mRNA in E.A. hy 926 cells induced by phorbol ester. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TP53 | down-regulates activity
binding
|
ETS1 |
0.52 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254087 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14586398 |
We demonstrate that p53 and ets-1 coregulate TXSA in an antagonistic and inter-related manner, with ets-1 being a potent transcriptional activator and p53 inhibiting ets-1-dependent transcription. We show that ets-1 and p53 associate physically in vitro and in vivo and that their interaction, rather than a direct binding of p53 to the TXSA promoter, is required for transcriptional repression of TXSA by wild-type p53. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ETS1 | up-regulates quantity by expression
transcriptional regulation
|
MMP13 |
0.304 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254084 |
|
|
Homo sapiens |
SKOV-3 Cell |
| pmid |
sentence |
| 22270366 |
VEGF-induced MMP-9 and MMP-13 promoter activities were down-regulated in ETS-1 siRNA-transfected cells. it is hypothesized that the activation of PI3K/AKT and p38 MAPK by VEGF results in ETS-1 gene expression, which activates MMP-9 and MMP-13, leading to the invasion and scattering of SKOV-3 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ETS1 | up-regulates quantity by expression
|
ITGA11 |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253352 |
|
|
Homo sapiens |
HT-1080 Cell |
| pmid |
sentence |
| 16300938 |
We speculate that the "mesenchymal signature" of alpha11 integrin gene expression is controlled by the activity of Sp1/Sp3, fibroblast-specific combinations of Ets family members and yet unidentified enhancer-binding transcription factors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ETS1 | down-regulates quantity by repression 
transcriptional regulation
|
BAX |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254204 |
|
|
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 17213822 |
Our results suggest that the interaction between ETS1 and GFI1 facilitates their binding to specific sites on the Bax promoter and represses Bax expression in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TLX1 | down-regulates activity
binding
|
ETS1 |
0.457 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259097 |
|
|
Homo sapiens |
T-lymphoblastic Leukemia Cell Line |
| pmid |
sentence |
| 22516263 |
We show that the cortical thymic maturation arrest in T-lineage ALLs that overexpress TLX1 or TLX3 is due to binding of TLX1/TLX3 to ETS1, leading to repression of T cell receptor (TCR) α enhanceosome activity and blocked TCR-Jα rearrangement. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ETS1 | up-regulates quantity by expression
transcriptional regulation
|
ATP2A3 |
0.324 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261601 |
|
|
Mus musculus |
Brain Cell Line |
| pmid |
sentence |
| 12119294 |
Ets-1 was able to transactivate the SERCA3 promoter in MoBr 204 as cotransfection of an Ets-1 expression vector increased the activity of the −97/+301-Luc construct by 6-fold. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ETS1 | up-regulates quantity by expression
transcriptional regulation
|
TNC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261599 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15001984 |
Sp1 and Ets1 are potent transactivators of the TN-C promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
ETS1
- 
- 