Summary

Name PPP2R1A
Full Name Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Synonyms Medium tumor antigen-associated 61 kDa protein, PP2A subunit A isoform PR65-alpha, PP2A subunit A isoform R1-alpha
Primary ID P30153
Links - -
Type protein
Relations 7
Function The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (PubMed:15525651). Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (PubMed:16580887).

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding PPP2CB 0.884
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding PP2CA_R1A_R2A 0.92
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPT 0.2
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding PP2Ca_R1A_Bd 0.881
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SGO1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PPP2CA 0.957
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding PP2Ca_R1A_Bd 0.904
Publications: 1 Organism: Homo Sapiens