| + |
PP2Ca_R1A_Bd | down-regulates activity 
dephosphorylation
|
AR |
0.293 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254759 |
Ser83 |
QQQQQETsPRQQQQQ |
Homo sapiens |
|
| pmid |
sentence |
| 27858941 |
DAB2IP acts as a scaffold protein for PP2A to suppress DHT-elicited S81 phosphorylation of the AR, preventing its nuclear translocation and binding to androgen response elements. In addition, DAB2IP can compete with the AR for binding to c-Src, thus blocking the non-genomic AR pathway |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PP2Ca_R1A_Bd | up-regulates activity 
dephosphorylation
|
GSK3B |
0.448 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254754 |
Ser9 |
SGRPRTTsFAESCKP |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20080667 |
DAB2IP interacts via its C2 domain with GSK3β, recruiting phosphatase PP2A for S9 de-phosphorylation and leading to GSK3β activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PP2Ca_R1A_Bd | up-regulates activity
dephosphorylation
|
MAP3K5 |
0.284 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254756 |
Ser966 |
NEYLRSIsLPVPVLV |
Homo sapiens |
|
| pmid |
sentence |
| 27858941 |
DAB2IP also mediates recruitment of PP2A to ASK1, binding both proteins through its C2 domain; this favors removal of the inhibitory S967 phosphorylation and further activation of ASK1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP2R1A | form complex 
binding
|
PP2Ca_R1A_Bd |
0.89 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243445 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23454242 |
[PP2A] ... is multifarious as it is composed of catalytic, scaffold and regulatory subunits. The catalytic and scaffold subunits have two isoforms and the regulatory subunit has four different families containing different isoforms. The regulatory subunit is the most diverse with temporal and spatial specificity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DAB2IP | up-regulates activity
binding
|
PP2Ca_R1A_Bd |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254753 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20080667 |
DAB2IP interacts via its C2 domain with GSK3β, recruiting phosphatase PP2A for S9 de-phosphorylation and leading to GSK3β activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP2CA | form complex
binding
|
PP2Ca_R1A_Bd |
0.84 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243442 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23454242 |
[PP2A] ... is multifarious as it is composed of catalytic, scaffold and regulatory subunits. The catalytic and scaffold subunits have two isoforms and the regulatory subunit has four different families containing different isoforms. The regulatory subunit is the most diverse with temporal and spatial specificity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PP2Ca_R1A_Bd | down-regulates activity
dephosphorylation
|
PDPK1 |
0.279 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243515 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21075311 |
Here, we show that PPP2R2B, encoding the B55² regulatory subunit of the PP2A complex, is epigenetically inactivated by DNA hypermethylation in colorectal cancer. B55²-associated PP2A interacts with PDK1 and modulates its activity toward Myc phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP2R2B | form complex
binding
|
PP2Ca_R1A_Bd |
0.771 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243507 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23454242 |
[PP2A] ... is multifarious as it is composed of catalytic, scaffold and regulatory subunits. The catalytic and scaffold subunits have two isoforms and the regulatory subunit has four different families containing different isoforms. The regulatory subunit is the most diverse with temporal and spatial specificity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
PP2Ca_R1A_Bd