Summary

Name PPM1A
Full Name Protein phosphatase 1A
Synonyms Protein phosphatase 2C isoform alpha, PP2C-alpha, Protein phosphatase IA | PPPM1A
Primary ID P35813
Links - -
Type protein
Relations 21
Pathways P38 Signaling
Function Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png dephosphorylation IKBKB 0.40
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation IKBKB
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation PAK1
Publications: 3 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png dephosphorylation PIK3R1
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png dephosphorylation PI3K
Publications: 1 Organism: Mus Musculus
+ img/unknown.png dephosphorylation CDK9 0.41
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation CDK9
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation AXIN1 0.55
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation GSK3B/Axin/APC
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png dephosphorylation AXIN1
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PPM1A
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation SMAD1 0.56
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation SMAD3 0.46
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation SMAD2 0.51
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation SMAD2 0.51
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK14 0.12
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ down-regulates img/direct_inhibition.png dephosphorylation SMAD3 0.46
Publications: 1 Organism: Homo Sapiens