| + |
ZEB1 | down-regulates quantity by repression 
transcriptional regulation
|
CDH1 |
0.674 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255158 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15311212 |
known E-cadherin transcriptional repressors, such as SLUG (SNAI2), SIP1 (ZEB2), TWIST1, SNAIL (SNAI1) and ZEB1 (TCF8), but not E12/E47 (TCF3), had a lack of upregulation in cells expressing mutated E-cadherin compared to WT. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FBXO45 | down-regulates quantity by destabilization 
binding
|
ZEB1 |
0.29 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272179 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 25460509 |
One of the hallmarks of EMT is loss of E-cadherin and gain of N-cadherin expression, which are regulated by the core EMT-inducing transcription factors (EMT-TFs), such as Zeb1/2, Snai1/2 and Twist1. Here, we find that EMT-TFs can be dynamically degraded by an atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 (SPFFbxo45) through the ubiquitin proteasome system (UPS). The key step is recognition of EMT-TFs by Fbxo45 through its SPRY domain for Zeb2, or F-box domain for the other three EMT-TFs Snai1, Snai2 and Twist1, respectively. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZEB1 | down-regulates quantity by repression
transcriptional regulation
|
GRHL2 |
0.444 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255623 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 23814079 |
we could further demonstrate that expression of GRHL2 is directly suppressed by the transcription factor zinc finger enhancer-binding protein 1 (ZEB1), which in turn is a direct target for repression by GRHL2, suggesting that the EMT transcription factors GRHL2 and ZEB1 form a double negative regulatory feedback loop in breast cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMARCA4 | up-regulates 
binding
|
ZEB1 |
0.413 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165017 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20418909 |
Zeb1 represses e-cadherin transcription / we reported that brg1 binds to the ntr of zeb1 acting as its co-repressor in the regulation of the e-cadherin promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DAB2IP | down-regulates quantity by repression
transcriptional regulation
|
ZEB1 |
0.271 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254772 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27858941 |
Through inhibition of PI3K–AKT signaling, DAB2IP also represses ZEB1, another CSC determinant. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Skp1-Pam E3 | down-regulates quantity by destabilization
polyubiquitination
|
ZEB1 |
0.253 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272186 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 25460509 |
One of the hallmarks of EMT is loss of E-cadherin and gain of N-cadherin expression, which are regulated by the core EMT-inducing transcription factors (EMT-TFs), such as Zeb1/2, Snai1/2 and Twist1. Here, we find that EMT-TFs can be dynamically degraded by an atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 (SPFFbxo45) through the ubiquitin proteasome system (UPS). The key step is recognition of EMT-TFs by Fbxo45 through its SPRY domain for Zeb2, or F-box domain for the other three EMT-TFs Snai1, Snai2 and Twist1, respectively. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SALL4 | up-regulates quantity by expression 
transcriptional regulation
|
ZEB1 |
0.255 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255123 |
|
|
Homo sapiens |
Breast Cancer Cell Line |
| pmid |
sentence |
| 23954296 |
Our shRNA-mediated SALL4 knockdown system and SALL4 overexpression system revealed that SALL4 suppresses the expression of adhesion gene CDH1, and positively regulates the CDH1 suppressor ZEB1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LBX1 | up-regulates quantity by expression
transcriptional regulation
|
ZEB1 |
0.333 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266054 |
|
|
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 19651985 |
Compared with the empty vector, LBX1 induced increased promoter activity of threefold to fourfold and fivefold to sixfold for ZEB1 and Snail1, respectively |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZEB1 | down-regulates quantity by repression
transcriptional regulation
|
EPCAM |
0.443 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255622 |
|
|
Homo sapiens |
Breast Cancer Cell, Pancreatic Cancer Cell |
| pmid |
sentence |
| 23667256 |
We found a similar ZEB1-dependent repression of EPCAM expression in human pancreatic and breast cancer cell lines, mediated through direct binding of ZEB1 to the EPCAM promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GRHL2 | down-regulates quantity by repression
transcriptional regulation
|
ZEB1 |
0.444 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255624 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 23814079 |
we could further demonstrate that expression of GRHL2 is directly suppressed by the transcription factor zinc finger enhancer-binding protein 1 (ZEB1), which in turn is a direct target for repression by GRHL2, suggesting that the EMT transcription factors GRHL2 and ZEB1 form a double negative regulatory feedback loop in breast cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZEB1 | down-regulates quantity by repression
transcriptional regulation
|
FBP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267596 |
|
|
Homo sapiens |
Lung Cancer Cell Line |
| pmid |
sentence |
| 30616754 |
Down-regulation of FBP1 by ZEB1-mediated repression confers to growth and invasion in lung cancer cells|we confirmed DNA methylation in the promoter contributed to the decrease of FBP1 expression in lung cancer cells. We identified Zinc finger E-box-binding homeobox 1 (ZEB1) bond to FBP1 promoter to enhance DNA methylation in lung cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ZEB1
- 
- 