3.0
Summary
| Name |  VHLView Modifications |
| Full Name | von Hippel-Lindau disease tumor suppressor |
| Synonyms | Protein G7, pVHL |
| Primary ID | P40337 |
| Links |  -  -  |
| Type | protein |
| Relations | 12 |
| Function | Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CHEK2 | up-regulates 
phosphorylation
|
VHL | 0.467 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NEK1 | down-regulates quantity by destabilization 
phosphorylation
|
VHL | 0.26 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | VHL | down-regulates activity
binding
|
CARD9 | 0.402 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | VHL | up-regulates quantity by expression 
transcriptional regulation
|
CDKN1C | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | VHL | down-regulates quantity by repression 
transcriptional regulation
|
KLF10 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | VHL | up-regulates quantity by stabilization
binding
|
TP53 | 0.464 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | VHL | down-regulates quantity by destabilization
ubiquitination
|
IREB2 | 0.366 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | VHL | form complex 
binding
|
VCB-Cul2 | 0.818 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | VHL | up-regulates quantity by expression
transcriptional regulation
|
DAB2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | VHL | up-regulates quantity by expression
transcriptional regulation
|
SPARC | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | VHL | down-regulates
ubiquitination
|
HIF-1 complex | 0.683 |
| Publications: | 1 | Organism: | Homo Sapiens | |