| + |
MMP13 | down-regulates quantity by destabilization 
cleavage
|
FGA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263612 |
Ala20 |
VVGTAWTaDSGEGDF |
in vitro |
|
| pmid |
sentence |
| 10930399 |
Matrix metalloproteinases collagenase-2, macrophage elastase, collagenase-3, and membrane type 1-matrix metalloproteinase impair clotting by degradation of fibrinogen and factor XII| We have now investigated the role of collagenase-2 (MMP-8), macrophage elastase (MMP-12), collagenase-3 (MMP-13), and membrane type 1-matrix metalloproteinase (MT1-MMP, MMP-14) in the degradation of fibrinogen and Factor XII of the plasma clotting system.|MMP-13 27YVATRDN g-chain| 20ADSGEGD a-chain| 124RNSVDXLNXN b-chain| 442LRTGKEKV a-chain |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263613 |
Leu442 |
TSKGDKElRTGKEKV |
in vitro |
|
| pmid |
sentence |
| 10930399 |
Matrix metalloproteinases collagenase-2, macrophage elastase, collagenase-3, and membrane type 1-matrix metalloproteinase impair clotting by degradation of fibrinogen and factor XII| We have now investigated the role of collagenase-2 (MMP-8), macrophage elastase (MMP-12), collagenase-3 (MMP-13), and membrane type 1-matrix metalloproteinase (MT1-MMP, MMP-14) in the degradation of fibrinogen and Factor XII of the plasma clotting system.|MMP-13 27YVATRDN g-chain| 20ADSGEGD a-chain| 124RNSVDXLNXN b-chain| 442LRTGKEKV a-chain |
|
| Publications: |
2 |
Organism: |
In Vitro |
| + |
MMP13 | down-regulates quantity by destabilization
cleavage
|
FGB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263615 |
Arg124 |
LQQERPIrNSVDELN |
in vitro |
|
| pmid |
sentence |
| 10930399 |
Matrix metalloproteinases collagenase-2, macrophage elastase, collagenase-3, and membrane type 1-matrix metalloproteinase impair clotting by degradation of fibrinogen and factor XII| We have now investigated the role of collagenase-2 (MMP-8), macrophage elastase (MMP-12), collagenase-3 (MMP-13), and membrane type 1-matrix metalloproteinase (MT1-MMP, MMP-14) in the degradation of fibrinogen and Factor XII of the plasma clotting system.|MMP-13 27YVATRDN g-chain| 20ADSGEGD a-chain| 124RNSVDXLNXN b-chain| 442LRTGKEKV a-chain |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
MMP13 | down-regulates quantity by destabilization
cleavage
|
F12 |
0.316 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263609 |
Gly376 |
SMTRVVGgLVALRGA |
in vitro |
|
| pmid |
sentence |
| 10930399 |
The data presented in this study show for the first time the degradation of Factor XII of the blood clotting system by matrix metalloproteinases. MMP-12, MMP-13, and MMP-14 cleave at Gly376Leu377|However, no activity of Factor XII can be observed after MMPinduced cleavage. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
MMP13 | down-regulates quantity by destabilization
cleavage
|
COL2A1 |
0.567 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256340 |
Gly906 |
EGPPGPQgLAGQRGI |
Homo sapiens |
|
| pmid |
sentence |
| 8609233 |
Although it appears that MMP-1 and MMP-13 both cleave type II collagen initially at the same site, MMP-13 affects a secondary cleavage to produce a 1/4-size collagen fragment with an NH2 terminus three amino acids removed from the primary cleavage site.The present work has demonstrated expression of MMP-13 in human osteoarthritic cartilage and shown that MMP-13 has significant type II collagen degrading activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MMP13 | down-regulates quantity by destabilization
cleavage
|
FGG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263614 |
Tyr27 |
LSSTCVAyVATRDNC |
in vitro |
|
| pmid |
sentence |
| 10930399 |
Matrix metalloproteinases collagenase-2, macrophage elastase, collagenase-3, and membrane type 1-matrix metalloproteinase impair clotting by degradation of fibrinogen and factor XII| We have now investigated the role of collagenase-2 (MMP-8), macrophage elastase (MMP-12), collagenase-3 (MMP-13), and membrane type 1-matrix metalloproteinase (MT1-MMP, MMP-14) in the degradation of fibrinogen and Factor XII of the plasma clotting system.|MMP-13 27YVATRDN g-chain| 20ADSGEGD a-chain| 124RNSVDXLNXN b-chain| 442LRTGKEKV a-chain |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
NfKb-p65/p50 | up-regulates quantity by expression 
transcriptional regulation
|
MMP13 |
0.316 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254800 |
|
|
Homo sapiens |
Chondrocyte Cell Line |
| pmid |
sentence |
| 12734180 |
The suppressive effect of IGF-1 and OP-1 on MMP-13 expression was due in part to down-regulation of the expression of pro-inflammatory cytokines and the activity of their intermediate molecules, including NF-kappaB and AP-1 factors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ING2 | up-regulates quantity by expression
transcriptional regulation
|
MMP13 |
0.401 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254491 |
|
|
Homo sapiens |
Colonic Adenocarcinoma Cell Line |
| pmid |
sentence |
| 19437536 |
ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ETS1 | up-regulates quantity by expression
transcriptional regulation
|
MMP13 |
0.315 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254084 |
|
|
Homo sapiens |
SKOV-3 Cell |
| pmid |
sentence |
| 22270366 |
VEGF-induced MMP-9 and MMP-13 promoter activities were down-regulated in ETS-1 siRNA-transfected cells. it is hypothesized that the activation of PI3K/AKT and p38 MAPK by VEGF results in ETS-1 gene expression, which activates MMP-9 and MMP-13, leading to the invasion and scattering of SKOV-3 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAF | up-regulates quantity by expression
transcriptional regulation
|
MMP13 |
0.256 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254560 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20067416 |
MMP-13 gene expression is regulated primarily at the transcriptional level. In this study, we investigated the role of c-maf in regulating MMP-13 transcription. Using transient transfection system with an c-maf construct, and MMP-13 promoter-luciferase constructs with specific mutations in transcription factor binding sites, we found that c-maf can significantly enhance MMP-13 promoter activity via the AP-1 sitecv |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IGF1 | down-regulates quantity by repression 
transcriptional regulation
|
MMP13 |
0.369 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254802 |
|
|
Homo sapiens |
Chondrocyte Cell Line |
| pmid |
sentence |
| 12734180 |
In the present study we investigated the inhibitory effects of IGF-1 and OP-1 on MMP-13 expression in human chondrocytes. We found that the suppressive effect of IGF-1 and OP-1 on the MMP-13 promoter activity was dose-dependent at the transcriptional level with a corresponding decrease in the level of MMP-13 protein. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SPDEF | down-regulates quantity by repression
transcriptional regulation
|
MMP13 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255219 |
|
|
Homo sapiens |
PrEC Cell |
| pmid |
sentence |
| 22761428 |
Transcriptional analysis of several genes associated with tumor metastasis, invasion, and the epithelial-mesenchymal transition demonstrated that SPDEF expression selectively down-regulated MMP9 and MMP13 in prostate cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RUNX2 | up-regulates quantity by expression
transcriptional regulation
|
MMP13 |
0.495 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255078 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15564063 |
Increased expression of RUNX2 in OA cartilage may contribute to increased expression of MMP-13. FGF2, which is present in OA synovial fluid, activated RUNX2 via the MEK/ERK pathway and increased MMP-13 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGF2 | up-regulates quantity by expression
transcriptional regulation
|
MMP13 |
0.439 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255079 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15564063 |
Increased expression of RUNX2 in OA cartilage may contribute to increased expression of MMP-13. FGF2, which is present in OA synovial fluid, activated RUNX2 via the MEK/ERK pathway and increased MMP-13 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HDAC4 | down-regulates quantity by repression
transcriptional regulation
|
MMP13 |
0.337 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254235 |
|
|
Homo sapiens |
UMR-106-01 Cell |
| pmid |
sentence |
| 17656568 |
We have hypothesized that histone deacetylases (HDACs) are involved with PTH-induced MMP-13 gene expression in the osteoblastic cell line, UMR 106-01. We have shown that PTH profoundly regulates HDAC4 in UMR 106-01 cells through a PKA-dependent pathway, leading to removal of HDAC4 from the MMP-13 promoter and its enhanced transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YBX1 | down-regulates quantity by repression
transcriptional regulation
|
MMP13 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255615 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17822788 |
YB-1 binds to the MMP-13 promoter sequence and represses MMP-13 transactivation via the AP-1 site. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MMP13 | up-regulates
|
ECM_disassembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272358 |
|
|
|
|
| pmid |
sentence |
| 17318226 |
Historically, MMPs were thought to function mainly as enzymes that degrade structural components of the ECM. |
|
| Publications: |
1 |
| + |
PTH | up-regulates quantity by expression
transcriptional regulation
|
MMP13 |
0.467 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254234 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17656568 |
Parathyroid hormone (PTH) functions as an essential regulator of calcium homeostasis and as a mediator of bone remodeling. We have already shown that PTH stimulates the expression of matrix metalloproteinase-13 (MMP-13), which is responsible for degrading components of extracellular matrix. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CITED2 | down-regulates quantity by repression
transcriptional regulation
|
MMP13 |
0.384 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253777 |
|
|
Homo sapiens |
C-28/I2 Cell |
| pmid |
sentence |
| 12960175 |
CITED2 plays a major role in shear-induced down-regulation of MMP-1 and MMP-13 via a transforming growth factor-beta-dependent pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT1 | down-regulates quantity by repression
transcriptional regulation
|
MMP13 |
0.298 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255235 |
|
|
Homo sapiens |
Chondrocyte |
| pmid |
sentence |
| 17179173 |
IFNgamma, through its receptor, activates STAT1, which binds with CBP/p300 coactivator, sequesters it from the cell system, and thus inhibits transcriptional induction of the MMP13 gene in chondrocytes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMP7 | down-regulates quantity by repression
transcriptional regulation
|
MMP13 |
0.362 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254801 |
|
|
Homo sapiens |
Chondrocyte Cell Line |
| pmid |
sentence |
| 12734180 |
In the present study we investigated the inhibitory effects of IGF-1 and OP-1 on MMP-13 expression in human chondrocytes. We found that the suppressive effect of IGF-1 and OP-1 on the MMP-13 promoter activity was dose-dependent at the transcriptional level with a corresponding decrease in the level of MMP-13 protein. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JUN | up-regulates quantity by expression
transcriptional regulation
|
MMP13 |
0.41 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254539 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20338993 |
The activated c-Jun protein has been proven to activate binding to the MMP-13 promoter and also upregulate the amount of MMP-13. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MMP13 | down-regulates
|
ECM |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272381 |
|
|
|
|
| pmid |
sentence |
| 17318226 |
Historically, MMPs were thought to function mainly as enzymes that degrade structural components of the ECM. |
|
| Publications: |
1 |
3.0
MMP13
- 
- 