| + |
IGF1R | down-regulates activity 
phosphorylation
|
CRK |
0.711 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251273 |
Tyr221 |
GGPEPGPyAQPSVNT |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 9480911 |
On activation of the IGF-I receptor, Crk-II binds to phosphorylated tyrosine residues, especially in the juxtamembrane region. As a result of this binding, the IGF-I receptor kinase phosphorylates Tyr-221 of Crk-II, resulting in a change in intramolecular folding and binding of the SH2 domain to the phosphorylated Tyr-221, which causes rapid disassociation of the Crk-II-IGF-I receptor complex. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ABL1 | down-regulates activity
phosphorylation
|
CRK |
0.752 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175135 |
Tyr221 |
GGPEPGPyAQPSVNT |
Homo sapiens |
|
| pmid |
sentence |
| 21779437 |
Negative regulation of crk by abl is essential for the antitumorigenic effects of ephrinb2,similar pathways may operate for crkl |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-173845 |
Tyr221 |
GGPEPGPyAQPSVNT |
Homo sapiens |
|
| pmid |
sentence |
| 21602891 |
Abl induces phosphorylation at y251 in vivo, and that the kinetics of phosphorylation at y251 and the negative regulatory y221 site in vitro are similar. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
ABL2 | down-regulates
phosphorylation
|
CRK |
0.684 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-136955 |
Tyr221 |
GGPEPGPyAQPSVNT |
Mus musculus |
|
| pmid |
sentence |
| 15886098 |
Rin1 binds to the abl sh3 and sh2 domains, and these interactions stimulate abl2 catalytic activity. This leads to increased phosphorylation of crk and crkl, inhibiting these cytoskeletal regulators by promoting intramolecular over intermolecular associations. the ability of crk to function as an adaptor protein is negatively regulated and terminated by phosphorylation on y221, which results in an intramolecular sh2-ptyr clamp, thereby resulting in the disassembly of crk-mediated signaling complexes |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-136958 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15886098 |
Abl2 kinase activity toward crk leads to increased phosphorylation of crk, inhibiting this cytoskeletal regulator by promoting intramolecular over intermolecular associations. |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Homo Sapiens |
| Tissue: |
Breast |
| + |
EGFR | down-regulates activity
phosphorylation
|
CRK |
0.732 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251091 |
Tyr221 |
GGPEPGPyAQPSVNT |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9642287 |
To address these questions, we have developed an antibody that specifically recognizes the CrkII protein phosphorylated on Tyr221, and we found that the EGF receptor directly phosphorylates CrkII on Tyr221. Furthermore, we observed that the phosphorylation of Tyr221 of CrkII correlated with its dissociation from the EGF receptor, implicating the phosphorylation of Tyr221 in the negative feedback of binding to the EGF receptor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CRK | up-regulates activity 
phosphorylation
|
PTK2 |
0.722 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250777 |
Tyr397 |
SVSETDDyAEIIDEE |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11314030 |
Tyrosine phosphorylation FAK was strictly dependent upon c-Crk II expression | Crk-inducible FAK tyrosine phosphorylation was completely abrogated by co-expression with R38K Crk (lane 2), and decreased by co-expression with W170K Crk (lane 3), indicating that the SH2 domain of c-Crk is absolutely essential for this effect. In contrast, mutants in the C-terminus of Crk that include Y222F c-Crk, which abrogates the c-Abl phosphorylation site, and W276K Crk, which mutates the C-terminal SH3 domain, modestly increased FAK activation compared to wild-type c-Crk II. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DOK4 | up-regulates
binding
|
CRK |
0.472 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-100996 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12730241 |
Insulin receptor-phosphorylated irs5/dok4 associates with rasgap, crk, src, and fyn, but not phosphatidylinositol 3-kinase p85, grb2, shp-2, nck, or phospholipase cgamma src homology 2 domains, and activates mapk in cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle, Kidney |
| + |
CRK | up-regulates
binding
|
CBL |
0.816 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-39241 |
|
|
Homo sapiens |
T-lymphocyte, Leukemia Cell |
| pmid |
sentence |
| 8524328 |
These results indicate that crk binds to c-cbl in a tyrosine phosphorylation-dependent manner. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CRK | up-regulates
binding
|
RAPGEF1 |
0.898 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-33732 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7806500 |
The endogenous c3g could be coprecipitated with crk from cell lysates of cells expressing high levels of c-crk or v-crk, suggesting high binding affinity and a possible interaction in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PDGFRB | up-regulates
binding
|
CRK |
0.591 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-185667 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19426560 |
Crk can interact directly with tyrosine kinase receptors and can transmit signals downstream |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-75884 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10733900 |
Crk could bind to both pdgf alpha- and beta-receptors in vivo |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
DOK7 | up-regulates activity
binding
|
CRK |
0.365 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273847 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 20603078 |
Here, we identify two tyrosine residues in Dok-7 that are phosphorylated by Agrin stimulation, and show that two proteins, Crk and Crk-L, are recruited to these phosphorylation sites in Dok-7. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PDGFRA | up-regulates
binding
|
CRK |
0.63 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-75881 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10733900 |
Crk could bind to both pdgf alpha- and beta-receptors in vivo. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-185664 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19426560 |
Crk can interact directly with tyrosine kinase receptors (for example pdgfr?) And can transmit signals downstream |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CRK | up-regulates
binding
|
MAP4K1 |
0.674 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-63988 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 9891069 |
We found that hpk1 interacted with crk and crkl adaptor proteins in vitro and in vivo and that the proline-rich motifs within hpk1 were involved in the differential interaction of hpk1 with the crk proteins and grb2. Crk and crkl not only activated hpk1 but also synergized with hpk1 in the activation of jnk. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | SAPK/JNK Signaling |
| + |
CRK | up-regulates activity
binding
|
MAP4K5 |
0.371 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262830 |
|
|
in vitro |
|
| pmid |
sentence |
| 9788432 |
Two novel candidates for signalling partners of Crk family adapter proteins, the hematopoietic progenitor kinase 1 (HPK1) and the kinase homologous to SPS1/STE20 (KHS), were found to bind with great selectivity to the first SH3 domains of c-Crk and CRKL.|These results make it likely that HPK1 and KHS participate in the signal transduction of Crk family adapter proteins in certain cell types. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
EPHA3 | up-regulates
binding
|
CRK |
0.609 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-115335 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11870224 |
Our results suggest that recruitment of crkii and activation of rho signalling are responsible for epha3-mediated cell rounding, blebbing and de-adhesion, and that ephrin-a5-mediated receptor clustering and epha3 tyrosine kinase activity are essential for this response |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP2K6 | up-regulates
phosphorylation
|
CRK |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-42384 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8663074 |
Mapkk6 was shown to phosphorylate and specifically activate the p38/mpk2 sub-family of the mitogen-activated protein kinase superfamily. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | SAPK/JNK Signaling |
3.0
CRK
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