Relation Results

Summary

Name MAP2K6
Full Name Dual specificity mitogen-activated protein kinase kinase 6
Synonyms MAP kinase kinase 6, MAPKK 6, MAPK/ERK kinase 6, MEK 6, Stress-activated protein kinase kinase 3, SAPK kinase 3, SAPKK-3, SAPKK3 | MEK6, MKK6, PRKMK6, SKK3
Primary ID P52564
Links - -
Type protein
Relations 31
Pathways COVID-19 Causal Network, FAP: BMP, FAP: TGF beta, Osteoblast: BMP, Osteoblast: TGF beta, P38 Signaling, P38 Signaling and Myogenesis, SAPK/JNK Signaling, SARS-CoV MAPK PERTURBATION, TGF-beta Signaling, Toll like receptors
Function Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the co ...
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Type: Score: Layout: SPV 
0.6390.3450.6510.7370.650.440.20.20.7370.7570.6470.4590.20.4160.6940.6020.20.45TAOK2MAP2K6STAT4MAPK13MAPK14MAPK12MAP3K1HSF4PAK6p38MAP3K7MAP3K4MAPK9MAP3K3MAPK11MAP3K5CRKMAPK10

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ TAOK2up-regulates activity img/direct-activation.png phosphorylation, binding MAP2K6 0.639
Identifier Residue Sequence Organism Cell Line
SIGNOR-106465 Ser207 ISGYLVDsVAKTIDA Homo sapiens HEK-293 Cell
pmid sentence
Suggesting that tao2 selectively activates mek3 and mek6 of the p38 pathway in intact cells
Identifier Residue Sequence Organism Cell Line
SIGNOR-70950 Homo sapiens
pmid sentence
Cotransfection experiments suggested that tao2 selectively activates mek3 and mek6 but not meks 1, 4, or 7.
Publications: 2 Organism: Homo Sapiens
Pathways:P38 Signaling
+ MAP2K6up-regulates activity img/direct-activation.png phosphorylation STAT4 0.345
Identifier Residue Sequence Organism Cell Line
SIGNOR-251425 Ser721 PSDLLPMsPSVYAVL Mus musculus NIH-3T3 Cell
pmid sentence
MKK6, phosphorylate STAT4 on serine 721. IL-12 induces STAT4 phosphorylation on serine 721 and that mutation of serine 721 interferes with STAT4 transcriptional activity.
Publications: 1 Organism: Mus Musculus
+ MAP2K6up-regulates activity img/direct-activation.png phosphorylation MAPK13 0.651
Identifier Residue Sequence Organism Cell Line
SIGNOR-251424 Thr180 RHADAEMtGYVVTRW in vitro
pmid sentence
SKK3 mediates the activation of SAPK4. Phosphorylation and activation of SAPK4 and SAPK2a by purified SKK3.
Identifier Residue Sequence Organism Cell Line
SIGNOR-273952 Thr180 RHADAEMtGYVVTRW Homo sapiens HEK-293 Cell
pmid sentence
p38-δ is activated by environmental stress, extracellular stimulants, and MAPK kinase-3, -4, -6, and -7. we investigated whether this Thr180-Gly-Tyr182 motif was essential for p38-δ activation. Taken together, these results suggest that the dual phosphorylation TGY motif is required for p38-δ activation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-273951 Tyr182 ADAEMTGyVVTRWYR Homo sapiens HEK-293 Cell
pmid sentence
p38-δ is activated by environmental stress, extracellular stimulants, and MAPK kinase-3, -4, -6, and -7. we investigated whether this Thr180-Gly-Tyr182 motif was essential for p38-δ activation. Taken together, these results suggest that the dual phosphorylation TGY motif is required for p38-δ activation.
Publications: 3 Organism: In Vitro, Homo Sapiens
+ MAP2K6up-regulates activity img/direct-activation.png phosphorylation MAPK14 0.737
Identifier Residue Sequence Organism Cell Line
SIGNOR-40423 Thr180 RHTDDEMtGYVATRW Chlorocebus aethiops
pmid sentence
These data indicate that mkk6 phosphorylates p38 map kinase on thr-180 and tyr-182, the sites of phosphorylation that activate p38 map kinase
Identifier Residue Sequence Organism Cell Line
SIGNOR-40427 Tyr182 TDDEMTGyVATRWYR Chlorocebus aethiops
pmid sentence
These data indicate that mkk6 phosphorylates p38 map kinase on thr-180 and tyr-182, the sites of phosphorylation that activate p38 map kinase
Identifier Residue Sequence Organism Cell Line
SIGNOR-236116 Homo sapiens COS-7 Cell
pmid sentence
A MAP kinase kinase kinase (MAPKKK), termed ASK1, was identified that activated two different subgroups of MAP kinase kinases (MAPKK), SEK1 (or MKK4) and MKK3/MAPKK6 (or MKK6), which in turn activated stress-activated protein kinase (SAPK, also known as JNK; c-Jun amino-terminal kinase) and p38 subgroups of MAP kinases, respectively.
Identifier Residue Sequence Organism Cell Line
SIGNOR-70607 Homo sapiens
pmid sentence
We have found that p38 mitogen-activated protein kinase, and its direct activator MKK6 are rapidly activated in response to TGF-beta.
Identifier Residue Sequence Organism Cell Line
SIGNOR-255780 Homo sapiens
pmid sentence
Expression of a constitutively active mutant of MKK6 (MKK6-glu) (39), but not a kinase-inactive mutant of MKK6 (MKK6-K82A) (39), strongly promoted human MSC differentiation to osteoblasts as shown by increased ALP activity and extracellular matrix mineralization (Figure 4E). Furthermore, MKK6-glu–expressing osteoblasts were treated with inhibitors of p38, JNK, and MEK (Figure 4F). Only treatment with the p38 inhibitor SB203580 blocked the effects of MKK6-glu.
Publications: 5 Organism: Chlorocebus Aethiops, Homo Sapiens
Pathways:P38 Signaling, P38 Signaling and Myogenesis, TGF-beta Signaling, Toll like receptors
+ MAP2K6up-regulates img/direct-activation.png phosphorylation MAPK12 0.65
Identifier Residue Sequence Organism Cell Line
SIGNOR-184134 Thr183 RQADSEMtGYVVTRW Homo sapiens
pmid sentence
Mapkk6 was shown to phosphorylate and specifically activate the p38/mpk2 sub of the mitogen-activated protein kinase superfamily . the p38 mapkinasekinasemkk6 is identified as a common activator of p38 alpha, p38 beta 2, and p38 gamma mapkinaseisoforms . p38mapks are activated by dual phosphorylation on a t-x-y motif in the activation loop through the action of map kinase kinases
Identifier Residue Sequence Organism Cell Line
SIGNOR-184138 Tyr185 ADSEMTGyVVTRWYR Homo sapiens
pmid sentence
Mapkk6 was shown to phosphorylate and specifically activate the p38/mpk2 sub of the mitogen-activated protein kinase superfamily . the p38 mapkinasekinasemkk6 is identified as a common activator of p38 alpha, p38 beta 2, and p38 gamma mapkinaseisoforms . p38mapks are activated by dual phosphorylation on a t-x-y motif in the activation loop through the action of map kinase kinases
Publications: 2 Organism: Homo Sapiens
+ MAP3K1up-regulates img/direct-activation.png phosphorylation MAP2K6 0.44
Identifier Residue Sequence Organism Cell Line
SIGNOR-59679 Thr211 LVDSVAKtIDAGCKP Homo sapiens
pmid sentence
Both wild type and kinase-inactive mutant rip immunoprecipitates can active mkk6 in vitrohe sapks are activated by at least two meks, sapk/erk kinase-1 (sek1, also called mapk-kinase (mkk)) and mkk7
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SAPK/JNK Signaling, SARS-CoV MAPK PERTURBATION, Toll like receptors
+ MAP2K6up-regulates activity img/direct-activation.png phosphorylation HSF4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-275493 Thr471 LGLPGALtIYSTPES
pmid sentence
Regulation of Hsf4b nuclear translocation and transcription activity by phosphorylation at threonine 472| At the upstream, MEK6 was found to interact with Hsf4b and enhance Hsf4b's nuclear translocation and transcription activity, probably by phosphorylation at sites such as T472. Taken together, our results suggest that phosphotylation of Hsf4b at T472 by protein kinases such as MEI
Publications: 1
+ MAP2K6up-regulates img/direct-activation.png phosphorylation PAK6 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-130975 Tyr566 KSLVGTPyWMAPEVI Homo sapiens
pmid sentence
Moreover, pak6 was directly activated by mkk6, and mutation of tyrosine 566 in a consensus mkk6 site (threonine-proline-tyrosine, tpy) in the activation loop of the pak6 kinase domain prevented activation by mkk6.
Publications: 1 Organism: Homo Sapiens
+ MAP2K6up-regulates activity img/direct-activation.png p38 0.737
Identifier Residue Sequence Organism Cell Line
SIGNOR-260721 Chlorocebus aethiops
pmid sentence
The p38 MAP kinase kinase MKK6 is identified as a common activator of p38 alpha, p38 beta 2, and p38 gamma MAP kinase isoforms
Identifier Residue Sequence Organism Cell Line
SIGNOR-260720 Homo sapiens
pmid sentence
P38 mitogen-activated protein kinase, and its direct activator MKK6 are rapidly activated in response to TGF-beta.
Publications: 2 Organism: Chlorocebus Aethiops, Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION
+ MAP3K7up-regulates activity img/direct-activation.png phosphorylation MAP2K6 0.757
Identifier Residue Sequence Organism Cell Line
SIGNOR-236145 Homo sapiens
pmid sentence
Tak1 can phosphorylate and activate map kinase kinase 3/6 (mkk3/6), and numerous studies have demonstrated a requirement for mkk3/6 activity in the initiation of myoblast differentiation, again in a p38-dependent manner.
Identifier Residue Sequence Organism Cell Line
SIGNOR-109497 Homo sapiens
pmid sentence
The activity of tak1 to phosphorylate mkk6, which activates the jnk-p38 kinase pathway, is directly regulated by k63-linked polyubiquitination
Publications: 2 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, P38 Signaling, P38 Signaling and Myogenesis, SAPK/JNK Signaling, SARS-CoV MAPK PERTURBATION, TGF-beta Signaling, Toll like receptors
+ MAP2K6up-regulates img/direct-activation.png phosphorylation MAPK13 0.651
Identifier Residue Sequence Organism Cell Line
SIGNOR-105698 Homo sapiens
pmid sentence
Mapkk6 was shown to phosphorylate and specifically activate the p38/mpk2 sub of the mitogen-activated protein kinase superfamily.
Identifier Residue Sequence Organism Cell Line
SIGNOR-42390 Homo sapiens
pmid sentence
Mapkk6 was shown to phosphorylate and specifically activate the p38/mpk2 sub of the mitogen-activated protein kinase superfamily.
Publications: 2 Organism: Homo Sapiens
+ MAP3K4up-regulates activity img/direct-activation.png phosphorylation MAP2K6 0.647
Identifier Residue Sequence Organism Cell Line
SIGNOR-50894 Homo sapiens COS-7 Cell
pmid sentence
These results, therefore, suggest that mtk1 directly phosphorylates and activates mkk3, mkk6 and sek1.
Identifier Residue Sequence Organism Cell Line
SIGNOR-62372 Homo sapiens HEK-293 Cell
pmid sentence
When truncated mapkkk4 (deltamapkkk4) was overexpressed in hek293 cells, it was constitutively activeco-expressed map kinase kinase (mkk)-1, mkk-4, mkk-3 and mkk-6 were activated in vivo by deltamapkkk4. All of the above mkks purified from escherichia coli were phosphorylated and activated by deltamapkkk4 immunoprecipitates in vitro.
Publications: 2 Organism: Homo Sapiens
Pathways:P38 Signaling
+ MAP2K6up-regulates img/direct-activation.png phosphorylation MAPK9 0.459
Identifier Residue Sequence Organism Cell Line
SIGNOR-45369 Homo sapiens
pmid sentence
A map kinase kinase kinase (mapkkk), termed ask1, was identified that activated two different subs of map kinase kinases (mapkk), sek1 (or mkk4) and mkk3/mapkk6 (or mkk6), which in turn activated stress-activated protein kinase (sapk, also known as jnk;c-jun amino-terminal kinase)
Publications: 1 Organism: Homo Sapiens
+ MAP2K6up-regulates activity img/direct-activation.png phosphorylation MAP2K6 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-236122 Homo sapiens HEK-293 Cell
pmid sentence
However, the autocatalytic activities of both mkk6 and mkk7 were enhanced by their coexpression with either mekk3 or mekk2.
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, P38 Signaling, P38 Signaling and Myogenesis, SAPK/JNK Signaling, SARS-CoV MAPK PERTURBATION, TGF-beta Signaling, Toll like receptors
+ MAP3K3up-regulates img/indirect-activation.png MAP2K6 0.416
Identifier Residue Sequence Organism Cell Line
SIGNOR-68020 Homo sapiens
pmid sentence
However, the autocatalytic activities of both mkk6 and mkk7 were enhanced by their coexpression with either mekk3 or mekk2.
Publications: 1 Organism: Homo Sapiens
+ MAP2K6up-regulates img/direct-activation.png phosphorylation MAPK11 0.694
Identifier Residue Sequence Organism Cell Line
SIGNOR-54947 Homo sapiens
pmid sentence
The p38 mapkinasekinasemkk6 is identified as a common activator of p38 alpha, p38 beta 2, and p38 gamma mapkinaseisoforms.
Publications: 1 Organism: Homo Sapiens
+ MAP3K5up-regulates activity img/direct-activation.png phosphorylation MAP2K6 0.602
Identifier Residue Sequence Organism Cell Line
SIGNOR-45353 Homo sapiens COS-7 Cell
pmid sentence
A MAP kinase kinase kinase (MAPKKK), termed ASK1, was identified that activated two different subgroups of MAP kinase kinases (MAPKK), SEK1 (or MKK4) and MKK3/MAPKK6 (or MKK6), which in turn activated stress-activated protein kinase (SAPK, also known as JNK; c-Jun amino-terminal kinase) and p38 subgroups of MAP kinases, respectively.
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling, P38 Signaling and Myogenesis
+ MAP2K6up-regulates img/direct-activation.png phosphorylation CRK 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-42384 Homo sapiens
pmid sentence
Mapkk6 was shown to phosphorylate and specifically activate the p38/mpk2 sub-family of the mitogen-activated protein kinase superfamily.
Publications: 1 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling
+ MAP2K6up-regulates img/direct-activation.png phosphorylation MAPK10 0.45
Identifier Residue Sequence Organism Cell Line
SIGNOR-45363 Homo sapiens
pmid sentence
A map kinase kinase kinase (mapkkk), termed ask1, was identified that activated two different subgroups of map kinase kinases (mapkk), sek1 (or mkk4) and mkk3/mapkk6 (or mkk6), which in turn activated stress-activated protein kinase (sapk, also known as jnk;c-jun amino-terminal kinase)
Publications: 1 Organism: Homo Sapiens
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