| + |
CDK1 |
phosphorylation
|
RAP1GAP |
0.448 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-18735 |
Ser484 |
SLIVPGKsPTRKKSG |
Homo sapiens |
|
| pmid |
sentence |
| 1406653 |
Two of the sites of phosphorylation by cyclic amp (camp)-dependent kinase were localized to serine residues 490 and 499, and one site of phosphorylation by p34cdc2 was localized to serine 484. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKACA |
phosphorylation
|
RAP1GAP |
0.309 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250043 |
Ser490 |
KSPTRKKsGPFGSRR |
in vitro |
|
| pmid |
sentence |
| 1406653 |
We have localized two of the sites of phosphorylation in vitro by cAMP-dependent kinase to serine residues 490 and 499. raplGAP undergoes phosphorylation at specific sites in vivo, the effects of phosphorylation on raplGAP have remained elusive. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250044 |
Ser499 |
PFGSRRSsAIGIENI |
in vitro |
|
| pmid |
sentence |
| 1406653 |
We have localized two of the sites of phosphorylation in vitro by cAMP-dependent kinase to serine residues 490 and 499. raplGAP undergoes phosphorylation at specific sites in vivo, the effects of phosphorylation on raplGAP have remained elusive. |
|
| Publications: |
2 |
Organism: |
In Vitro |
| + |
PLK1 | down-regulates 
phosphorylation
|
RAP1GAP |
0.455 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205577 |
Ser525 |
AGQKTPDsGHVSQEP |
Homo sapiens |
|
| pmid |
sentence |
| 25329897 |
Plk1 phosphorylates ser525 in conserved 524dsghvs529 degron of rap1gap and promotes its interaction with _-trcp. Together, these results further support a model in which plk1, but not cdk1 or gsk-3_-mediated phosphorylation of rap1gap is a prerequisite for mitotic degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAP1GAP | down-regulates activity
binding
|
AKT |
0.308 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278056 |
|
|
Homo sapiens |
HUVEC Cell |
| pmid |
sentence |
| 22173489 |
Overexpression of Rap1GAP significantly inhibited Rap1 activation, ERK and Akt phosphorylation of HUVECs compared with pcDNA transfection controls |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAP1GAP | down-regulates activity
binding
|
ERK1/2 |
0.33 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278055 |
|
|
Homo sapiens |
HUVEC Cell |
| pmid |
sentence |
| 22173489 |
Overexpression of Rap1GAP significantly inhibited Rap1 activation, ERK and Akt phosphorylation of HUVECs compared with pcDNA transfection controls |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BTRC | down-regulates
ubiquitination
|
RAP1GAP |
0.343 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-203548 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25329897 |
Here, we demonstrated that rap1gap is ubiquitinated and degraded through proteasome pathway in mitosis. Proteolysis of rap1gap requires the plk1 kinase and _-trcp ubiquitin ligase complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAP1GAP | down-regulates activity
binding
|
RAP1A |
0.836 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278054 |
|
|
Homo sapiens |
HUVEC Cell |
| pmid |
sentence |
| 22173489 |
Overexpression of Rap1GAP significantly inhibited Rap1 activation, ERK and Akt phosphorylation of HUVECs compared with pcDNA transfection controls |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAP1GAP | down-regulates activity
binding
|
GNAZ |
0.35 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278053 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10593970 |
Biochemical analysis using purified recombinant proteins revealed that the physical interaction between Gaz and Rap1GAP blocks the ability of RGSs (regulators of G protein signaling) to stimulate GTP hydrolysis of the a subunit, and also attenuates the ability of activated Gaz to inhibit adenylyl cyclase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
RAP1GAP
- 
- 