Summary

Name GRIA4
Full Name Glutamate receptor 4
Synonyms GluR-4, GluR4, AMPA-selective glutamate receptor 4, GluR-D, Glutamate receptor ionotropic, AMPA 4, GluA4 | GLUR4
Primary ID P48058
Links - -
Type protein
Relations 12
Function Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation GRIA4 0.501
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation GRIA4 0.412
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GRIA4 0.57
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GRIA4 0.689
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GRIA4 0.547
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation GRIA4 0.547
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png chemical activation GRIA4 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png post transcriptional regulation GRIA4 0.2
Publications: 1 Organism: Mus Musculus
Tissue: Spinal Cord
+ up-regulates quantity img/direct-activation.png relocalization GRIA4 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates quantity img/direct-activation.png relocalization calcium(2+) 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png binding GRIA4 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Excitatory_synaptic_transmission 0.7
Publications: 1 Organism: Homo Sapiens