Relation Results

Summary

Name BLK
Full Name Tyrosine-protein kinase Blk
Synonyms B lymphocyte kinase, p55-Blk
Primary ID P51451
Links - -
Type protein
Relations 10
Pathways B-cell activation
Function Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling (By similarity). B-cell receptor (BCR) signaling requ ...
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Type: Score: Layout: SPV 
0.20.440.20.20.6440.6440.6440.644BLKCGASFCGR2AFCGR2CSOCS1BCR-DkBCR-MkBCR-DlBCR-Ml

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ BLKdown-regulates activity img/direct_inhibition.png phosphorylation CGAS 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-275844 Tyr215 LLNTGSYyEHVKISA
pmid sentence
DNA damage induces nuclear translocation of cGAS in a manner that is dependent on importin-α, and the phosphorylation of cGAS at tyrosine 215-mediated by B-lymphoid tyrosine kinase-facilitates the cytosolic retention of cGAS.
Publications: 1
+ BLKup-regulates activity img/direct-activation.png phosphorylation FCGR2A 0.44
Identifier Residue Sequence Organism Cell Line
SIGNOR-249311 Tyr288 YETADGGyMTLNPRA in vitro
pmid sentence
To identify the FcgammaRII-phosphorylating protein tyrosine kinase (PTK), we used the combination of an in vitro and an in vivo approach. In an in vitro assay using recombinant cytoplasmic tails of the different FcgammaRII isoforms as well as tyrosine exchange mutants, we show that each of the BCR-associated PTKs (Lyn, Blk, Fyn, and Syk) shows different phosphorylation patterns with regard to the different FcgammaR isoforms and point|Fyn and Blk definitely phosphorylate Y-282 in the ITAM of Fc_RIIa/c, whereas the non-ITAM tyrosine residue (Y-275) becomes phosphorylated by Syk, as the phosphorylation of double point mutants shows. In addi-tion to these tyrosine residues, Fyn, Blk, and Syk might phosphorylate the most C-terminal tyrosine residue (Y-298) because altering this tyrosine residue together with one of the tyrosine residues clearly shown to be phosphorylated by the respective PTK results in the abrogation of phosphorylation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-249312 Tyr304 TDDDKNIyLTLPPND in vitro
pmid sentence
To identify the FcgammaRII-phosphorylating protein tyrosine kinase (PTK), we used the combination of an in vitro and an in vivo approach. In an in vitro assay using recombinant cytoplasmic tails of the different FcgammaRII isoforms as well as tyrosine exchange mutants, we show that each of the BCR-associated PTKs (Lyn, Blk, Fyn, and Syk) shows different phosphorylation patterns with regard to the different FcgammaR isoforms and point|Fyn and Blk definitely phosphorylate Y-282 in the ITAM of Fc_RIIa/c, whereas the non-ITAM tyrosine residue (Y-275) becomes phosphorylated by Syk, as the phosphorylation of double point mutants shows. In addi-tion to these tyrosine residues, Fyn, Blk, and Syk might phosphorylate the most C-terminal tyrosine residue (Y-298) because altering this tyrosine residue together with one of the tyrosine residues clearly shown to be phosphorylated by the respective PTK results in the abrogation of phosphorylation.
Publications: 2 Organism: In Vitro
+ BLKup-regulates activity img/direct-activation.png phosphorylation FCGR2C 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-262672 Tyr294 YETADGGyMTLNPRA in vitro
pmid sentence
Fyn and Blk definitely phosphorylate Y-282 in the ITAM of FcgRIIa/c, whereas the non-ITAM tyrosine residue (Y-275) becomes phosphorylated by Syk, as the phosphorylation of double point mutants shows. In addition to these tyrosine residues, Fyn, Blk, and Syk might phosphorylate the most C-terminal tyrosine residue (Y-298) because altering this tyrosine residue together with one of the tyrosine residues clearly shown to be phosphorylated by the respective PTK results in the abrogation of phosphorylation
Identifier Residue Sequence Organism Cell Line
SIGNOR-262673 Tyr310 TDDDKNIyLTLPPND in vitro
pmid sentence
Fyn and Blk definitely phosphorylate Y-282 in the ITAM of FcgRIIa/c, whereas the non-ITAM tyrosine residue (Y-275) becomes phosphorylated by Syk, as the phosphorylation of double point mutants shows. In addition to these tyrosine residues, Fyn, Blk, and Syk might phosphorylate the most C-terminal tyrosine residue (Y-298) because altering this tyrosine residue together with one of the tyrosine residues clearly shown to be phosphorylated by the respective PTK results in the abrogation of phosphorylation
Publications: 2 Organism: In Vitro
+ BLKdown-regulates activity img/direct_inhibition.png phosphorylation SOCS1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277889 Tyr80 LLDACGFyWGPLSVH in vitro
pmid sentence
These findings show that SOCS1 phosphorylation by the SRC family inhibits its tumor-suppressive activity, indicating that patients with increased SOCS1 phosphorylation may benefit from SRC family kinase inhibitors.
Publications: 1 Organism: In Vitro
+ BLKup-regulates activity img/direct-activation.png phosphorylation BCR-Dk 0.644
Identifier Residue Sequence Organism Cell Line
SIGNOR-268214 Homo sapiens B-lymphocyte
pmid sentence
The CD79 molecules contain signaling molecules called immunoreceptor tyrosine-based activation motifs (ITAMs) in their intracellular portion. ITAMs are bound by the SRC kinases such as LYN, FYN and B-lymphoid tyrosine kinase (BLK). The crosslinking of BCR by specific antigens induces phosphorylation of ITAM tyrosines by these SRC kinases.
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation
+ BLKup-regulates activity img/direct-activation.png phosphorylation BCR-Mk 0.644
Identifier Residue Sequence Organism Cell Line
SIGNOR-268208 Homo sapiens B-lymphocyte
pmid sentence
The CD79 molecules contain signaling molecules called immunoreceptor tyrosine-based activation motifs (ITAMs) in their intracellular portion. ITAMs are bound by the SRC kinases such as LYN, FYN and B-lymphoid tyrosine kinase (BLK). The crosslinking of BCR by specific antigens induces phosphorylation of ITAM tyrosines by these SRC kinases.
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation
+ BLKup-regulates activity img/direct-activation.png phosphorylation BCR-Dl 0.644
Identifier Residue Sequence Organism Cell Line
SIGNOR-268217 Homo sapiens B-lymphocyte
pmid sentence
The CD79 molecules contain signaling molecules called immunoreceptor tyrosine-based activation motifs (ITAMs) in their intracellular portion. ITAMs are bound by the SRC kinases such as LYN, FYN and B-lymphoid tyrosine kinase (BLK). The crosslinking of BCR by specific antigens induces phosphorylation of ITAM tyrosines by these SRC kinases.
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation
+ BLKup-regulates activity img/direct-activation.png phosphorylation BCR-Ml 0.644
Identifier Residue Sequence Organism Cell Line
SIGNOR-268211 Homo sapiens B-lymphocyte
pmid sentence
The CD79 molecules contain signaling molecules called immunoreceptor tyrosine-based activation motifs (ITAMs) in their intracellular portion. ITAMs are bound by the SRC kinases such as LYN, FYN and B-lymphoid tyrosine kinase (BLK). The crosslinking of BCR by specific antigens induces phosphorylation of ITAM tyrosines by these SRC kinases.
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation
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