3.0
Summary
| Name |  PRPS1View Modifications |
| Full Name | Ribose-phosphate pyrophosphokinase 1 |
| Synonyms | PPRibP, Phosphoribosyl pyrophosphate synthase I, PRS-I | |
| Primary ID | P60891 |
| Links |  -  -  |
| Type | protein |
| Relations | 10 |
| Pathways | Pentose phosphate pathway |
| Inhibitors | GDP; AMP; ADP |
| Function | Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CDK1 | up-regulates activity 
phosphorylation
|
PRPS1 | 0.259 |
| Publications: | 1 | |||
| + | AMPK | down-regulates activity 
phosphorylation
|
PRPS1 | 0.246 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PRKAA1 | down-regulates activity
phosphorylation
|
PRPS1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KHK | up-regulates activity
phosphorylation
|
PRPS1 | 0.355 |
| Publications: | 1 | |||
| + | PRPS1 | up-regulates quantity
chemical modification
|
5-phospho-α-D-ribose 1-diphosphate | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Pentose phosphate pathway | |||
| + | PRPS1 | up-regulates 
|
Nucleotide_synthesis | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Pentose phosphate pathway | |||
| + | GDP | down-regulates activity
chemical inhibition
|
PRPS1 | 0.8 |
| Publications: | 1 | |||
| + | AMP | down-regulates activity
chemical inhibition
|
PRPS1 | 0.8 |
| Publications: | 1 | |||
| + | ADP | down-regulates activity
chemical inhibition
|
PRPS1 | 0.8 |
| Publications: | 1 | |||
| + | PRPS1 | down-regulates quantity
chemical modification
|
D-ribofuranose 5-phosphate(2-) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Pentose phosphate pathway | |||