Summary

Name RBX1
Full Name E3 ubiquitin-protein ligase RBX1
Synonyms Protein ZYP, RING finger protein 75, RING-box protein 1, Rbx1, Regulator of cullins 1 | RNF75, ROC1
Primary ID P62877
Links - -
Type protein
Relations 11
Function E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair (PubMed:10230407, PubMed:10579999, PubMed:15983046, PubMed:16678110, PubMed:19112177, PubMed:19679664, PubMed:23455478, PubMed:27565346, PubMed:29769719, PubMed:11961546, PubMed:22748924). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (PubMed:27565346). The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Recruits the E2 ubiquitin-conjugating enzyme CDC34 to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41. In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM.

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Relations

Regulator Mechanism target score ℹ
+ RBX1form complex img/form-complex.png binding VCB-Cul2 0.793
Publications: 1 Organism: Homo Sapiens
+ RBX1form complex img/form-complex.png binding Cullin 1-RBX1-Skp1 0.953
Publications: 1 Organism: Homo Sapiens
+ RBX1form complex img/form-complex.png binding Cullin 3-RBX1-Skp1 0.928
Publications: 1 Organism: Homo Sapiens
+ RBX1form complex img/form-complex.png binding BAF250b E3 ligase 0.599
Publications: 1 Organism: Homo Sapiens
+ RBX1up-regulates img/direct-activation.png ubiquitination NFKB1 0.422
Publications: 1 Organism: Homo Sapiens
+ RBX1form complex img/form-complex.png binding DCX DET1-COP1 0.863
Publications: 1 Organism: Homo Sapiens
+ RBX1form complex img/form-complex.png binding Cullin4-RBX1-DDB1 0.83
Publications: 1 Organism: Homo Sapiens
+ RBX1down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination ESR1 0.35
Publications: 1 Organism: Homo Sapiens
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination RBX1 0.2
Publications: 1 Organism: Homo Sapiens
+ RBX1up-regulates img/direct-activation.png ubiquitination NFKB2 0.286
Publications: 1 Organism: Homo Sapiens
+ RBX1form complex img/form-complex.png binding Cullin 7-RBX1-Skp1 0.838
Publications: 1 Organism: Homo Sapiens