Summary

Name CACNA1B
Full Name Voltage-dependent N-type calcium channel subunit alpha-1B
Synonyms Brain calcium channel III, BIII, Calcium channel, L type, alpha-1 polypeptide isoform 5, Voltage-gated calcium channel subunit alpha Cav2.2 | CACH5, CACNL1A5
Primary ID Q00975
Links - -
Type protein
Relations 5
Pathways GABAergic synapse
Function Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by omega-conotoxin-GVIA (AC P01522) (AC P01522) (By similarity). They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation CACNA1B 0.323
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CACNA1B 0.2
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates activity img/direct_inhibition.png binding CACNA1B 0.396
Publications: 1 Organism: Homo Sapiens
Pathways:GABAergic synapse
+ up-regulates quantity img/direct-activation.png relocalization calcium(2+) 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:GABAergic synapse
+ up-regulates quantity img/direct-activation.png binding CACNA1B 0.267
Publications: 1 Organism: Mus Musculus
Tissue: Brain