| + |
PRKCA | down-regulates activity 
phosphorylation
|
EWSR1 |
0.337 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-52850 |
Ser266 |
SSYGQQSsFRQDHPS |
Homo sapiens |
|
| pmid |
sentence |
| 9341188 |
Here we report thatews, a nuclearrna-bindingprooncoprotein, contains an iq domain, is phosphorylated byproteinkinase c, and interacts with calmodulin. Interestingly, pkc phosphorylation of ews inhibits its binding to rna homopolymers, and conversely,rna binding to ews interferes with pkc phosphorylation./ these data indicate that ews contains an iq domain with ser266 acting as the primary site for pkc phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKCB | down-regulates activity
phosphorylation
|
EWSR1 |
0.279 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-52854 |
Ser266 |
SSYGQQSsFRQDHPS |
Homo sapiens |
|
| pmid |
sentence |
| 9341188 |
Here we report thatews, a nuclearrna-bindingprooncoprotein, contains an iq domain, is phosphorylated byproteinkinase c, and interacts with calmodulin. Interestingly, pkc phosphorylation of ews inhibits its binding to rna homopolymers, and conversely,rna binding to ews interferes with pkc phosphorylation./ these data indicate that ews contains an iq domain with ser266 acting as the primary site for pkc phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 |
phosphorylation
|
EWSR1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182778 |
Thr79 |
QPPTGYTtPTAPQAY |
Homo sapiens |
|
| pmid |
sentence |
| 19076070 |
Here we report that ews and ews-fli1 become phosphorylated at thr79 . but the p38_/p38_ mapks were the major kinases phosphorylating ews-fli1. It will be important to investigate how the p38_/p38_-stimulated phosphorylation of ews-fusion proteins affects their ability to transactivate and their oncogenic potential. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK3 |
phosphorylation
|
EWSR1 |
0.268 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182782 |
Thr79 |
QPPTGYTtPTAPQAY |
Homo sapiens |
|
| pmid |
sentence |
| 19076070 |
Here we report that ews and ews-fli1 become phosphorylated at thr79 in the n-terminal domain in response to mitogens or dna damage. Mitogen-induced phosphorylation of ews and ews-fli1 was weak and catalysed by erk1 (extracellular signal-regulated kinase 1) and erk2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK11 |
phosphorylation
|
EWSR1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182774 |
Thr79 |
QPPTGYTtPTAPQAY |
Homo sapiens |
|
| pmid |
sentence |
| 19076070 |
Here we report that ews and ews-fli1 become phosphorylated at thr79 . but the p38_/p38_ mapks were the major kinases phosphorylating ews-fli1. It will be important to investigate how the p38_/p38_-stimulated phosphorylation of ews-fusion proteins affects their ability to transactivate and their oncogenic potential. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK1 |
phosphorylation
|
EWSR1 |
0.251 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182770 |
Thr79 |
QPPTGYTtPTAPQAY |
Homo sapiens |
|
| pmid |
sentence |
| 19076070 |
Here we report that ews and ews-fli1 become phosphorylated at thr79 in the n-terminal domain in response to mitogens or dna damage. Mitogen-induced phosphorylation of ews and ews-fli1 was weak and catalysed by erk1 (extracellular signal-regulated kinase 1) and erk2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SF1 | down-regulates
binding
|
EWSR1 |
0.428 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-58928 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9660765 |
Here we report that zfm1 also interacts withews / overexpression of zfm1 in hepg2 cells represses the transactivation of reporter gene expression driven by gal4-ews-ntd fusion protein and this repression correlates with zfm1 binding to ews. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERK1/2 |
phosphorylation
|
EWSR1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270172 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19076070 |
Here we report that ews and ews-fli1 become phosphorylated at thr79 in the n-terminal domain in response to mitogens or dna damage. Mitogen-induced phosphorylation of ews and ews-fli1 was weak and catalysed by erk1 (extracellular signal-regulated kinase 1) and erk2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Gbeta |
phosphorylation
|
EWSR1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270062 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19076070 |
Here we report that ews and ews-fli1 become phosphorylated at thr79 in the n-terminal domain in response to mitogens or dna damage. Mitogen-induced phosphorylation of ews and ews-fli1 was weak and catalysed by erk1 (extracellular signal-regulated kinase 1) and erk2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
EWSR1
- 
- 