3.0
Summary
| Name |  PAX5View Modifications |
| Full Name | Paired box protein Pax-5 |
| Synonyms | B-cell-specific transcription factor, BSAP |
| Primary ID | Q02548 |
| Links |  -  -  |
| Type | protein |
| Relations | 10 |
| Function | Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage (PubMed:10811620, PubMed:27181361). Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes (PubMed:10811620, PubMed:27181361). In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage (PubMed:32612238). Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire (PubMed:32612238). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MAPK3 | down-regulates activity 
phosphorylation
|
PAX5 | 0.25 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ERK1/2 | down-regulates activity
phosphorylation
|
PAX5 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAPK1 | down-regulates activity
phosphorylation
|
PAX5 | 0.358 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PAX5 | down-regulates quantity
transcriptional regulation
|
PRDM1 | 0.518 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | IL21 | up-regulates quantity by expression 
transcriptional regulation
|
PAX5 | 0.255 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PAX5 | down-regulates activity
binding
|
BZLF1 | |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SYK | down-regulates activity
phosphorylation
|
PAX5 | 0.434 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PRDM1 | down-regulates quantity
transcriptional regulation
|
PAX5 | 0.518 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | PRDM1 | down-regulates quantity by repression 
transcriptional regulation
|
PAX5 | 0.518 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PAX5 | down-regulates activity
binding
|
TLE4 | 0.581 |
| Publications: | 1 | Organism: | Homo Sapiens | |