| + |
DUSP2 | down-regulates 
dephosphorylation
|
MAPK1 |
0.744 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-40915 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8626452 |
Pac1 and mkp-1 previously have been implicated in the in vivo inactivation of erk or of erk and jnk, respectively. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK4 | up-regulates activity 
phosphorylation
|
DUSP2 |
0.354 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278959 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28252035 |
However, co-expression of ERK4 significantly increased the half-life of DUSP2 (XREF_FIG).|In support of the latter notion we have shown that wild-type ERK4 can phosphorylate DUSP2 in vitro and future studies will be aimed at identifying the relevant site (s) of modification and determining their influence on DUSP2 stability. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DUSP2 | down-regulates activity
dephosphorylation
|
MAPK6 |
0.376 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277069 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28252035 |
DUSP2 can dephosphorylate both ERK3 and ERK4 when expressed in mammalian cells.|Finally, we demonstrate that DUSP2 inhibits ERK3 and ERK4 mediated activation of MK5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DUSP2 | down-regulates
dephosphorylation
|
MAPK14 |
0.622 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-40918 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 8626452 |
We show that the in vivo substrate specificities of individual phosphatases are unique. Pac1, mkp-2, and mkp-1 recognize erk and p38, erk and jnk, and erk, p38, and jnk, respectively |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DUSP2 | down-regulates activity
dephosphorylation
|
MAPK4 |
0.354 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277068 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28252035 |
DUSP2 can dephosphorylate both ERK3 and ERK4 when expressed in mammalian cells.|Finally, we demonstrate that DUSP2 inhibits ERK3 and ERK4 mediated activation of MK5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
DUSP2
- 
- 