+ |
MAPKAPK5 | up-regulates
phosphorylation
|
MAPK4 |
0.63 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-17069 |
Ser186 |
YSHKGYLsEGLVTKW |
Homo sapiens |
|
pmid |
sentence |
1319925 |
This is due to mk5-dependent phosphorylation and only this retarded erk4 species is both phosphorylated on ser(186) and co-immunoprecipitates with wild-type mk5. We conclude that binding between erk4 and mk5 facilitates phosphorylation of ser(186) and stabilization of the erk4-mk5 complex. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MAPK4 | up-regulates activity
phosphorylation
|
MAPKAPK5 |
0.63 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-279072 |
Thr182 |
IDQGDLMtPQFTPYY |
Homo sapiens |
|
pmid |
sentence |
20734105 |
ERK3, ERK4 and p38 MAPK can all phosphorylate MK5 at Thr 182 , , , - ], but it is not known whether these enzymes also can phosphorylate Ser 115 and whether this modification contributes to ERK3-, ERK4-, or p38 MAPK -regulated subcellular localization of MK5. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MAPK4 | up-regulates activity
phosphorylation
|
AKT1 |
0.272 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-275450 |
Thr308 |
KDGATMKtFCGTPEY |
Homo sapiens |
HCT-116 Cell |
pmid |
sentence |
30688659 |
Mechanistically, MAPK4 directly bound and activated AKT by phosphorylation of the activation loop at threonine 308. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MAPK4 | up-regulates activity
phosphorylation
|
DUSP2 |
0.354 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-278959 |
|
|
Homo sapiens |
|
pmid |
sentence |
28252035 |
However, co-expression of ERK4 significantly increased the half-life of DUSP2 (XREF_FIG).|In support of the latter notion we have shown that wild-type ERK4 can phosphorylate DUSP2 in vitro and future studies will be aimed at identifying the relevant site (s) of modification and determining their influence on DUSP2 stability. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
DUSP2 | down-regulates activity
dephosphorylation
|
MAPK4 |
0.354 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-277068 |
|
|
Homo sapiens |
|
pmid |
sentence |
28252035 |
DUSP2 can dephosphorylate both ERK3 and ERK4 when expressed in mammalian cells.|Finally, we demonstrate that DUSP2 inhibits ERK3 and ERK4 mediated activation of MK5. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |