3.0
Summary
| Name |  KHDRBS1View Modifications |
| Full Name | KH domain-containing, RNA-binding, signal transduction-associated protein 1 |
| Synonyms | GAP-associated tyrosine phosphoprotein p62, Src-associated in mitosis 68 kDa protein, Sam68, p21 Ras GTPase-activating protein-associated p62, p68 | SAM68 |
| Primary ID | Q07666 |
| Links |  -  -  |
| Type | protein |
| Relations | 11 |
| Function | Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (By similarity). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MAPK1 | up-regulates 
phosphorylation
|
KHDRBS1 | 0.652 |
| Publications: | 3 | Organism: | Homo Sapiens | |
| + | CDK1 |
phosphorylation
|
KHDRBS1 | 0.516 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PTK6 |
phosphorylation
|
KHDRBS1 | 0.738 |
| Publications: | 3 | Organism: | Homo Sapiens | |
| + | BANP | down-regulates activity 
binding
|
KHDRBS1 | 0.314 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KHDRBS1 | down-regulates activity
binding
|
CREBBP | 0.387 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PTK6 | up-regulates
phosphorylation
|
KHDRBS1 | 0.738 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KHDRBS1 | up-regulates activity
post transcriptional regulation
|
NRXN1 | 0.338 |
| Publications: | 1 | Organism: | Mus Musculus | |