Summary

Name KHDRBS1
Full Name KH domain-containing, RNA-binding, signal transduction-associated protein 1
Synonyms GAP-associated tyrosine phosphoprotein p62, Src-associated in mitosis 68 kDa protein, Sam68, p21 Ras GTPase-activating protein-associated p62, p68 | SAM68
Primary ID Q07666
Links - -
Type protein
Relations 11
Function Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (By similarity). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation KHDRBS1 0.65
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation KHDRBS1 0.511
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation KHDRBS1 0.738
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation KHDRBS1 0.738
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding CREBBP 0.386
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding KHDRBS1 0.313
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png post transcriptional regulation NRXN1 0.342
Publications: 1 Organism: Mus Musculus