Summary

Name PAK2
Full Name Serine/threonine-protein kinase PAK 2
Synonyms Gamma-PAK, PAK65, S6/H4 kinase, p21-activated kinase 2, PAK-2, p58
Primary ID Q13177
Links - -
Type protein
Relations 45
Function Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation MYLK 0.516
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PAK2 0.2
Publications: 7 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation PAK2 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MYL12A 0.475
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation PAK2 0.244
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PAK2 0.244
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRL 0.341
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RPS6 0.316
Publications: 4 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation CASP7 0.358
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation VIM 0.313
Publications: 4 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation MKNK1 0.431
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NF2 0.491
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ABL1 0.425
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation SORT1 0.2
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation SYN1 0.333
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png phosphorylation PAK2 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PAK2 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation JUN 0.27
Publications: 5 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PAK2 0.547
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation PAK2 0.263
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PAK2 0.742
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding PAK2 0.881
Publications: 1 Organism: Mus Musculus