Summary

Name BIRC2
Full Name Baculoviral IAP repeat-containing protein 2
Synonyms Cellular inhibitor of apoptosis 1, C-IAP1, IAP homolog B, Inhibitor of apoptosis protein 2, hIAP-2, hIAP2, RING finger protein 48, TNFR2-TRAF-signaling complex protein 2 | API1, MIHB, RNF48
Primary ID Q13490
Links - -
Type protein
Relations 30
Pathways NF-KB Non Canonical
Inhibitors AT-406
Function Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions

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Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png chemical inhibition BIRC2 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png polyubiquitination RIPK3 0.662
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BIRC2 0.426
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination RIPK1 0.76
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding BIRC2 0.468
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png polyubiquitination RIPK4 0.362
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png polyubiquitination, ubiquitination RIPK1 0.76
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png polyubiquitination RIPK2 0.634
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CASP2 0.516
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png binding BIRC2 0.891
Publications: 2 Organism: In Vitro, Homo Sapiens
+ up-regulates activity img/direct-activation.png binding BIRC2 0.867
Publications: 2 Organism: Homo Sapiens
Pathways:NF-KB Non Canonical
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination BIRC2 0.315
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination BIRC2 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:NF-KB Non Canonical
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination PACS2 0.307
Publications: 1 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination DIABLO 0.891
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination TRAF2 0.867
Publications: 2 Organism: Homo Sapiens
Pathways:NF-KB Non Canonical
+ down-regulates img/direct_inhibition.png binding BIRC2 0.428
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding BIRC2 0.686
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding BIRC2 0.891
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination UBE2J1 0.377
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination CSE1L 0.338
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png ubiquitination BIRC2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BIRC2 0.535
Publications: 1 Organism: Homo Sapiens