Summary

Name ARHGEF7
Full Name Rho guanine nucleotide exchange factor 7
Synonyms Beta-Pix, COOL-1, PAK-interacting exchange factor beta, p85 | COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Primary ID Q14155
Links - -
Type protein
Relations 7
Function Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation ARHGEF7 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ARHGEF7 0.47
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CBLC 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png RAC1 0.618
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding LRRK2 0.47
Publications: 1 Organism: Homo Sapiens