| + |
PRKCG | up-regulates 
phosphorylation
|
ARHGEF7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205234 |
Ser518 |
LSASPRMsGFIYQGK |
Homo sapiens |
|
| pmid |
sentence |
| 25009260 |
Pkc_ directly phosphorylates _pix at ser583 and indirectly at ser340 in cells. herefore, we propose that pkc_ positively modulates dopamine release through _2pix phosphorylation. The pkc_-_pix-cdc42/rac1 phosphorylation axis may provide a new therapeutic target for the treatment of parkinsonian syndrome |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205238 |
Ser761 |
DSLGRRSsLSRLEPS |
Homo sapiens |
|
| pmid |
sentence |
| 25009260 |
Pkc_ directly phosphorylates _pix at ser583 and indirectly at ser340 in cells. herefore, we propose that pkc_ positively modulates dopamine release through _2pix phosphorylation. The pkc_-_pix-cdc42/rac1 phosphorylation axis may provide a new therapeutic target for the treatment of parkinsonian syndrome |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
LRRK2 | up-regulates
phosphorylation
|
ARHGEF7 |
0.468 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169221 |
Thr127 |
KVLSSLVtLNKVTAD |
Homo sapiens |
|
| pmid |
sentence |
| 21048939 |
Arhgef7 is interacting with lrrk2 in vitro and in vivo. Lrrk2 phosphorylates arhgef7 in vitro.Two Threonine residues, t107 and t143, within the arhgef7 n-terminus were identified with high confidence |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169225 |
Thr164 |
LGSQSLHtRTSKLFQ |
Homo sapiens |
|
| pmid |
sentence |
| 21048939 |
Arhgef7 is interacting with lrrk2 in vitro and in vivo. Lrrk2 phosphorylates arhgef7 in vitro.Two Threonine residues, t107 and t143, within the arhgef7 n-terminus were identified with high confidence |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
ARHGEF7 | up-regulates
binding
|
LRRK2 |
0.468 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169217 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21048939 |
Arhgef7 is interacting with lrrk2 in vitro and in vivo. Gtpase activity of full-length lrrk2 increases in the presence of recombinant arhgef7. Arhgef7 might act as a guanine nucleotide exchange factor for lrrk2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ARHGEF7 | up-regulates 
|
RAC1 |
0.621 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-155744 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17562871 |
We propose that the association of plcgamma1 with complexes containing git1 and beta-pix is essential for its role in integrin-mediated cell spreading and motility. As a component of this complex, plcgamma1 is also involved in the activation of cdc42 and rac1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ARHGEF7 | down-regulates 
binding
|
CBLC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-118135 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14505571 |
Here, we show that activation of cdc42 protects the egf receptor from the negative regulatory activity of the c-cbl ubiquitin ligase. Activated cdc42 binds to p85cool-1 (for cloned-out-of-library)/beta-pix (for pak-interactive exchange factor), a protein that directly associates with c-cbl. This inhibits the binding of cbl by the egf receptor and thus prevents cbl from catalyzing receptor ubiquitination |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ARHGEF7
- 
- 