Summary

Name FZD2
Full Name Frizzled-2
Synonyms Fz-2, hFz2, FzE2
Primary ID Q14332
Links - -
Type protein
Relations 17
Pathways FAP: Wnt
Function Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:25759469). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding LRP5 0.668
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png SETDB1/NLK/CHD7 0.399
Publications: 1
+ down-regulates img/direct_inhibition.png relocalization, ubiquitination FZD2 0.294
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination FZD2 0.294
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png CEBPA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding FZD2 0.753
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding LRP6 0.648
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DVL1 0.646
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DVL2 0.629
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding FZD2 0.753
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization FZD2 0.312
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png PPARG 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding FZD2 0.739
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DVL3 0.62
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding FZD2 0.619
Publications: 1 Organism: Homo Sapiens