Summary

Name MED1
Full Name Mediator of RNA polymerase II transcription subunit 1
Synonyms Activator-recruited cofactor 205 kDa component, ARC205, Mediator complex subunit 1, Peroxisome proliferator-activated receptor-binding protein, PBP, PPAR-binding protein, Thyroid hormone receptor-associated protein complex 220 kDa component, Trap220, Thyroid receptor-interacting protein 2, TR-interacting protein 2, TRIP-2, Vitamin D receptor-interacting protein complex component DRIP205, p53 regulatory protein RB18A | ARC205, CRSP1, CRSP200, DRIP205, DRIP230, PBP, PPARBP, PPARGBP, RB18A, TRAP220, TRIP2
Primary ID Q15648
Links - -
Type protein
Relations 7
Function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ MAPK1up-regulates img/direct-activation.png phosphorylation MED1 0.355
Publications: 2 Organism: Homo Sapiens
+ MAPK3up-regulates img/direct-activation.png phosphorylation MED1 0.263
Publications: 2 Organism: Homo Sapiens
+ ERK1/2up-regulates img/direct-activation.png phosphorylation MED1 0.2
Publications: 1 Organism: Homo Sapiens
+ Gbetaup-regulates img/direct-activation.png phosphorylation MED1 0.2
Publications: 1 Organism: Homo Sapiens
+ MED1form complex img/form-complex.png binding Core mediator complex 0.81
Publications: 1 Organism: Homo Sapiens