| + |
PCSK7 | up-regulates 
phosphorylation
|
ATF6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-89813 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12076252 |
We discovered that azc, an agent that causes the formation of abnormal proteins, stimulates the stress-activated kinase p38 mapk, which phosphorylates atf6 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PCSK7 | down-regulates 
phosphorylation
|
CDC25B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-107423 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11333986 |
We propose that regulation of cdc25b phosphorylation by p38 is a critical event for initiating the g2/m checkpoint after ultraviolet radiation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PCSK7 | up-regulates
phosphorylation
|
ELK4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-47771 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9130707 |
In contrast, the tcf sap-1a is efficiently phosphorylated by p38 map kinase in vitro and in vivo on the homologous residues ser381 and ser387 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PCSK7 | up-regulates
phosphorylation
|
PPP2CA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105783 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11259586 |
This together with the rapid kinetics of pp1-pp2a activation following p38 activation suggests that pp1 and/or pp2a complexes are direct targets for p38-mediated phosphorylation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PCSK7 | down-regulates
phosphorylation
|
CEBPA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-186202 |
|
|
Homo sapiens |
Neutrophil |
| pmid |
sentence |
| 19544470 |
Addition of active p38a induced phosphorylation of wild-type c/ebp_? (c/ebp_?WT) on serine 21 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PCSK7 | down-regulates
phosphorylation
|
KHSRP |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-143167 |
|
|
Homo sapiens |
Myoblast |
| pmid |
sentence |
| 16364914 |
Ksrp phosphorylated by p38 displays compromised binding to are-containing transcripts and fails to promote their rapid decay,although it retains the ability to interact with the mrna degradation machinery. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| + |
SB-202190 | down-regulates
chemical inhibition
|
PCSK7 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-60130 |
|
|
Homo sapiens |
Monocyte |
| pmid |
sentence |
| 9738669 |
Sb202190, a selective inhibitor of p38 mitogen activated protein kinase, is a powerful regulator of lps-induced mrnas in monocytes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
(-)-anisomycin | up-regulates
chemical activation
|
PCSK7 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-145496 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16581040 |
These results indicate that activation of p38 mapk by anisomycin induces ltd and subsequently occludes electrically induced ltd |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
PCSK7 | down-regulates
phosphorylation
|
ETV6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-95622 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12435397 |
In vivo p38-dependent phosphorylation reduced trans-repressional abilities of tel through ets-binding consensus site |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PCSK7 | up-regulates 
|
RELA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235734 |
|
|
Mus musculus |
C2C12 Cell, Myoblast |
| pmid |
sentence |
| 14767066 |
Treatment with sb203580 significantly reduced this cooperation, consistent with the idea that p38 indirectly stimulates the transactivating activity of p65 through a mechanism involving cbp. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
PCSK7 | down-regulates 
|
DDB2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-181278 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18806262 |
The data suggest that p38 mapk is involved in serine phosphorylation of ddb2, which may influence its ubiquitylation following irradiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PCSK7 | down-regulates
|
NFKBIA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235837 |
|
|
Mus musculus |
C2C12 Cell, Myoblast |
| pmid |
sentence |
| 14767066 |
The levels of ikb_? Where reduced in cells overexpressing mkk6 [] these results indicated that mkk6 was able to promote the degradation of the NF-kappaB inhibitor, in a p38-dependent manner. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Muscle, Skeletal Muscle |
3.0
PCSK7
- 
- 