| + |
STK4 | up-regulates 
phosphorylation
|
MOB1B |
0.857 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175837 |
Thr12 |
FGSRSSKtFKPKKNI |
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Mob1, which forms a complex with lats1/2, is also phosphorylated by mst1/2, resulting in an enhanced lats1/2mob1 interaction. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201314 |
Thr12 |
FGSRSSKtFKPKKNI |
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
Mob1, when phosphorylated by MST1/2, binds to the autoinhibitory motif in Lats1/2, which in turn leads to the phosphorylation of the Lats activation loop (Lats1 S909 and Lats2 S872) and thereby an increase of their kinase activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201318 |
Thr35 |
LLKHAEAtLGSGNLR |
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
Mob1, when phosphorylated by MST1/2, binds to the autoinhibitory motif in Lats1/2, which in turn leads to the phosphorylation of the Lats activation loop (Lats1 S909 and Lats2 S872) and thereby an increase of their kinase activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175841 |
Thr35 |
LLKHAEAtLGSGNLR |
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Mob1, which forms a complex with lats1/2, is also phosphorylated by mst1/2, resulting in an enhanced lats1/2mob1 interaction. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
STK3 | up-regulates
phosphorylation
|
MOB1B |
0.823 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175813 |
Thr12 |
FGSRSSKtFKPKKNI |
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Mob1, which forms a complex with lats1/2, is also phosphorylated by mst1/2, resulting in an enhanced lats1/2 mob1 interaction. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201290 |
Thr12 |
FGSRSSKtFKPKKNI |
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
Mob1, when phosphorylated by MST1/2, binds to the autoinhibitory motif in Lats1/2, which in turn leads to the phosphorylation of the Lats activation loop (Lats1 S909 and Lats2 S872) and thereby an increase of their kinase activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175817 |
Thr35 |
LLKHAEAtLGSGNLR |
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Mob1, which forms a complex with lats1/2, is also phosphorylated by mst1/2, resulting in an enhanced lats1/2 mob1 interaction. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201294 |
Thr35 |
LLKHAEAtLGSGNLR |
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
Mob1, when phosphorylated by MST1/2, binds to the autoinhibitory motif in Lats1/2, which in turn leads to the phosphorylation of the Lats activation loop (Lats1 S909 and Lats2 S872) and thereby an increase of their kinase activity |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
PTPN5 | up-regulates activity
dephosphorylation
|
MOB1B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277058 |
Tyr26 |
IPEGSHQyELLKHAE |
Homo sapiens |
|
| pmid |
sentence |
| 28675297 |
PTPN5 dephosphorylates\nMob1a at Y26 residue. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MOB1B | up-regulates
binding
|
LATS2 |
0.881 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169798 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21084559 |
Lats1/2 are activated by association with the highly homologous scaffold proteins mps one binder kinase activator-like 1a (mobkl1a) and 1b (mobkl1b), which are collectively referred to as mob1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
MOB1B | up-regulates
binding
|
LATS1/2 |
0.923 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269865 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21084559 |
Lats1/2 are activated by association with the highly homologous scaffold proteins mps one binder kinase activator-like 1a (mobkl1a) and 1b (mobkl1b), which are collectively referred to as mob1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
STK3/4 | up-regulates
phosphorylation
|
MOB1B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270221 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Mob1, which forms a complex with lats1/2, is also phosphorylated by mst1/2, resulting in an enhanced lats1/2 mob1 interaction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
MOB1B | up-regulates
binding
|
LATS1 |
0.923 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169795 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21084559 |
Lats1/2 are activated by association with the highly homologous scaffold proteins mps one binder kinase activator-like 1a (mobkl1a) and 1b (mobkl1b), which are collectively referred to as mob1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
MSI2 | down-regulates quantity 
post transcriptional regulation
|
MOB1B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282659 |
|
|
Homo sapiens |
Pancreatic Ductal Carcinoma Cell |
| pmid |
sentence |
| 32780197 |
Musashi 2 (MSI2), a member of the Musashi RNA-binding family, is reported to be an oncoprotein in pancreatic ductal adenocarcinoma (PDAC) Overexpression of MSI2 promoted PDAC cells proliferation, migration and invasion. Further studies demonstrated that MSI2 regulated the Hippo signaling pathway via directly binding to the mRNAs of SAV1 and MOB1, and controlled the translation and stability of SAV1 and the translation of MOB1. This study demonstrated that MSI2 regulated the Hippo signaling pathway via suppressing SAV1 and MOB1 at post-transcriptional level and promoted PDAC progression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
MOB1B
- 
- 