+ |
STK3 | up-regulates
phosphorylation
|
RCC1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-263145 |
Ser11 |
KRIAKRRsPPADAIP |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
19559616 |
MST2 Phosphorylates RCC1 In Vitro and In Vivo. Using an antibody generated against phospho-S2/11 in RCC1 [18], we found that these two residues were also efficiently phosphorylated by MST1 and MST2 (Figure 2D), further supporting that S2 and/or S11 are genuine MST2 phosphorylation targets. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-263146 |
Ser2 |
sPKRIAKR |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
19559616 |
MST2 Phosphorylates RCC1 In Vitro and In Vivo. Using an antibody generated against phospho-S2/11 in RCC1 [18], we found that these two residues were also efficiently phosphorylated by MST1 and MST2 (Figure 2D), further supporting that S2 and/or S11 are genuine MST2 phosphorylation targets. |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
STK3 | up-regulates
phosphorylation
|
NEK2 |
0.247 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-169539 |
Ser438 |
EKNYQLKsRQILGMR |
Homo sapiens |
|
pmid |
sentence |
21076410 |
Our data suggest that mst2 phosphorylates nek2a thereby recruiting nek2a to centrosomes and promoting phosphorylation and displacement of centrosomal linker proteins |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
STK3 | up-regulates
phosphorylation
|
LATS2 |
0.586 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-201274 |
Ser872 |
HQRCLAHsLVGTPNY |
Homo sapiens |
|
pmid |
sentence |
23431053 |
MST1/2 directly phosphorylate Lats1/2 at the hydrophobic motif (Lats1 T1079 and Lats2 T1041), and this phosphorylation is required for Lats1/2 activation |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-175797 |
Ser872 |
HQRCLAHsLVGTPNY |
Homo sapiens |
|
pmid |
sentence |
21808241 |
Activation of mst1/2 leads to phosphorylation and activation of their direct substrates, lats1/2. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-201278 |
Thr1041 |
EHAFYEFtFRRFFDD |
Homo sapiens |
|
pmid |
sentence |
23431053 |
MST1/2 directly phosphorylate Lats1/2 at the hydrophobic motif (Lats1 T1079 and Lats2 T1041), and this phosphorylation is required for Lats1/2 activation |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-175801 |
Thr1041 |
EHAFYEFtFRRFFDD |
Homo sapiens |
|
pmid |
sentence |
21808241 |
Activation of mst1/2 leads to phosphorylation and activation of their direct substrates, lats1/2. |
|
Publications: |
4 |
Organism: |
Homo Sapiens |
Pathways: | Hippo Signaling |
+ |
STK3 | up-regulates
phosphorylation
|
LATS1 |
0.598 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-133544 |
Ser909 |
HQRCLAHsLVGTPNY |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
15688006 |
Since the N-terminal half of Lats1 (residues 1588) was dispensable for the activation of Lats1 by Mst2, mass spectrometry was used to identify phosphorylation sites within the C-terminal domain of Lats1. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-132927 |
Thr1079 |
EHAFYEFtFRRFFDD |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
15688006 |
Since the N-terminal half of Lats1 (residues 1588) was dispensable for the activation of Lats1 by Mst2, mass spectrometry was used to identify phosphorylation sites within the C-terminal domain of Lats1. |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
Pathways: | Hippo Signaling |
+ |
AKT2 | down-regulates
phosphorylation
|
STK3 |
0.265 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-164302 |
Thr117 |
IIRLRNKtLIEDEIA |
Homo sapiens |
Breast Cancer Cell |
pmid |
sentence |
20231902 |
Akt phosphorylates mst2 at thr117 in vitro and in vivo, which leads to mst2 cleavage and kinase activity as well as nuclear translocation. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
AKT3 | down-regulates
phosphorylation
|
STK3 |
0.276 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-164306 |
Thr117 |
IIRLRNKtLIEDEIA |
Homo sapiens |
Breast Cancer Cell |
pmid |
sentence |
20231902 |
Akt phosphorylates mst2 at thr117 in vitro and in vivo, which leads to mst2 cleavage and kinase activity as well as nuclear translocation. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
AKT1 | down-regulates
phosphorylation
|
STK3 |
0.363 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-252509 |
Thr117 |
IIRLRNKtLIEDEIA |
Homo sapiens |
Breast Cancer Cell |
pmid |
sentence |
20231902 |
Akt phosphorylates mst2 at thr117 in vitro and in vivo, which leads to mst2 cleavage and kinase activity as well as nuclear translocation. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-163533 |
Thr117 |
IIRLRNKtLIEDEIA |
Homo sapiens |
|
pmid |
sentence |
20086174 |
We determined that mst2 phosphorylation by akt limits mst2 activity in two ways: first, by blocking its binding to rassf1a and by promoting its association into the raf-1 inhibitory complex, and second, by preventing homodimerization of mst2, which is needed for its activation. we identified t117 and t384 as akt phosphorylation sites in mst2. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-163537 |
Thr384 |
GTMKRNAtSPQVQRP |
Homo sapiens |
|
pmid |
sentence |
20086174 |
We determined that mst2 phosphorylation by akt limits mst2 activity in two ways: first, by blocking its binding to rassf1a and by promoting its association into the raf-1 inhibitory complex, and second, by preventing homodimerization of mst2, which is needed for its activation. we identified t117 and t384 as akt phosphorylation sites in mst2. |
|
Publications: |
3 |
Organism: |
Homo Sapiens |
+ |
AKT | down-regulates
phosphorylation
|
STK3 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-244345 |
Thr117 |
IIRLRNKtLIEDEIA |
Homo sapiens |
|
pmid |
sentence |
20086174 |
We determined that mst2 phosphorylation by akt limits mst2 activity in two ways: first, by blocking its binding to rassf1a and by promoting its association into the raf-1 inhibitory complex, and second, by preventing homodimerization of mst2, which is needed for its activation. we identified t117 and t384 as akt phosphorylation sites in mst2. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-164298 |
Thr117 |
IIRLRNKtLIEDEIA |
Homo sapiens |
Breast Cancer Cell |
pmid |
sentence |
20231902 |
Akt phosphorylates mst2 at thr117 in vitro and in vivo, which leads to mst2 cleavage and kinase activity as well as nuclear translocation. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-244349 |
Thr384 |
GTMKRNAtSPQVQRP |
Homo sapiens |
|
pmid |
sentence |
20086174 |
We determined that mst2 phosphorylation by akt limits mst2 activity in two ways: first, by blocking its binding to rassf1a and by promoting its association into the raf-1 inhibitory complex, and second, by preventing homodimerization of mst2, which is needed for its activation. we identified t117 and t384 as akt phosphorylation sites in mst2. |
|
Publications: |
3 |
Organism: |
Homo Sapiens |
+ |
STK3 | up-regulates
phosphorylation
|
MOB1A |
0.841 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-175805 |
Thr12 |
FSSRSSKtFKPKKNI |
Homo sapiens |
|
pmid |
sentence |
21808241 |
Mob1, which forms a complex with lats1/2, is also phosphorylated by mst1/2, resulting in an enhanced lats1/2 mob1 interaction. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-201282 |
Thr12 |
FSSRSSKtFKPKKNI |
Homo sapiens |
|
pmid |
sentence |
23431053 |
Mob1, when phosphorylated by MST1/2, binds to the autoinhibitory motif in Lats1/2, which in turn leads to the phosphorylation of the Lats activation loop (Lats1 S909 and Lats2 S872) and thereby an increase of their kinase activity |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-201286 |
Thr35 |
LLKHAEAtLGSGNLR |
Homo sapiens |
|
pmid |
sentence |
23431053 |
Mob1, when phosphorylated by MST1/2, binds to the autoinhibitory motif in Lats1/2, which in turn leads to the phosphorylation of the Lats activation loop (Lats1 S909 and Lats2 S872) and thereby an increase of their kinase activity |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-175809 |
Thr35 |
LLKHAEAtLGSGNLR |
Homo sapiens |
|
pmid |
sentence |
21808241 |
Mob1, which forms a complex with lats1/2, is also phosphorylated by mst1/2, resulting in an enhanced lats1/2 mob1 interaction. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-177977 |
Thr74 |
QINMLYGtITEFCTE |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
18362890 |
These findings indicate that the phosphorylation of mob1 at thr74 by mst2 is essential to make a complex of mob1, mst2 and ndr1, and to fully activate ndr1 |
|
Publications: |
5 |
Organism: |
Homo Sapiens |
Pathways: | Hippo Signaling |
+ |
STK3 | up-regulates
phosphorylation
|
MOB1B |
0.807 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-175813 |
Thr12 |
FGSRSSKtFKPKKNI |
Homo sapiens |
|
pmid |
sentence |
21808241 |
Mob1, which forms a complex with lats1/2, is also phosphorylated by mst1/2, resulting in an enhanced lats1/2 mob1 interaction. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-201290 |
Thr12 |
FGSRSSKtFKPKKNI |
Homo sapiens |
|
pmid |
sentence |
23431053 |
Mob1, when phosphorylated by MST1/2, binds to the autoinhibitory motif in Lats1/2, which in turn leads to the phosphorylation of the Lats activation loop (Lats1 S909 and Lats2 S872) and thereby an increase of their kinase activity |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-201294 |
Thr35 |
LLKHAEAtLGSGNLR |
Homo sapiens |
|
pmid |
sentence |
23431053 |
Mob1, when phosphorylated by MST1/2, binds to the autoinhibitory motif in Lats1/2, which in turn leads to the phosphorylation of the Lats activation loop (Lats1 S909 and Lats2 S872) and thereby an increase of their kinase activity |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-175817 |
Thr35 |
LLKHAEAtLGSGNLR |
Homo sapiens |
|
pmid |
sentence |
21808241 |
Mob1, which forms a complex with lats1/2, is also phosphorylated by mst1/2, resulting in an enhanced lats1/2 mob1 interaction. |
|
Publications: |
4 |
Organism: |
Homo Sapiens |
Pathways: | Hippo Signaling |
+ |
PPP2CA | down-regulates
dephosphorylation
|
STK3 |
0.677 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-201266 |
Thr180 |
DTMAKRNtVIGTPFW |
Homo sapiens |
|
pmid |
sentence |
23431053 |
Rassf1a apparently protects mst1/2 against inactivation by pp2a, the phosphatases that dephosphorylate the stimulatory thr-183 and thr-180 of mst1 andmst2, respectively. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
STK3 | up-regulates
phosphorylation
|
STK3 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-164310 |
Thr180 |
DTMAKRNtVIGTPFW |
Homo sapiens |
Breast Cancer Cell |
pmid |
sentence |
20231902 |
Consistent with previous studies, sts alone induces mst2 cleavage and autophosphorylation of thr180, an indicator of mst2 activation, as well as apoptosis. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Hippo Signaling |
+ |
STK3 | down-regulates
phosphorylation
|
ABL1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-181056 |
Thr735 |
DTEWRSVtLPRDLQS |
Homo sapiens |
|
pmid |
sentence |
18794806 |
Here, we identify clk1, clk4, mst1, mst2 and ttk (also known as mps1) as novel thr735 kinases in vitro / phosphorylation of thr735 in c-abl is critical for binding to 14-3-3 |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
ABL1 | up-regulates
phosphorylation
|
STK3 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-197538 |
Tyr81 |
MQQCDSPyVVKYYGS |
Homo sapiens |
Neuron |
pmid |
sentence |
22590567 |
We demonstrate that c-abl kinase phosphorylates mst2 at an evolutionarily conserved site, y81, within the kinase domain. We further show that the phosphorylation of mst2 by c-abl leads to the disruption of the interaction with raf-1 proteins and the enhancement of homodimerization of mst2 proteins. It thereby enhances the mst2 activation and induces neuronal cell death. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
STK3 | up-regulates
phosphorylation
|
Mob1 |
0.851 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-269855 |
|
|
Homo sapiens |
|
pmid |
sentence |
21808241 |
Mob1, which forms a complex with lats1/2, is also phosphorylated by mst1/2, resulting in an enhanced lats1/2 mob1 interaction. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Hippo Signaling |
+ |
Cell-Cell_contact | up-regulates
|
STK3 |
0.7 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-230696 |
|
|
Homo sapiens |
|
pmid |
sentence |
22683405 |
In response to growth inhibitory signal (e.g. cellcell contact), MST1/2 in active form phosphorylates LATS1/2 that sequentially phosphorylates YAP at Ser-127. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Hippo Signaling |
+ |
SAV1 | up-regulates
binding
|
STK3 |
0.823 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-169829 |
|
|
Homo sapiens |
|
pmid |
sentence |
21084559 |
Mst is activated by binding of salvador (sav1, sav in drosophila), which is, in turn, also phosphorylated by mst. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Hippo Signaling |
+ |
okadaic acid | up-regulates
|
STK3 |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-201551 |
|
|
Homo sapiens |
|
pmid |
sentence |
23493077 |
Okadaic acid has been frequently used to enhance the phosphorylation of mst1 and mst2 and to trigger the activation of the hippo pathway. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
STK3 | up-regulates
phosphorylation
|
SAV1 |
0.823 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-230716 |
|
|
in vitro |
HEK-293 Cell |
pmid |
sentence |
16930133 |
In vitro phosphorylation experiments indicate that the phosphorylation of Sav by Mst is direct. The stabilizing effect of Mst was much greater on N-terminally truncated hSav mutants, as long as they retained the ability to bind Mst. Mst mutants that lacked the C-terminal coiled-coil domain and were unable to bind to hSav, also failed to stabilize or phosphorylate hSav |
|
Publications: |
1 |
Organism: |
In Vitro |
Pathways: | Hippo Signaling |
+ |
RASSF1 | up-regulates
binding
|
STK3 |
0.681 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-175790 |
|
|
Homo sapiens |
|
pmid |
sentence |
21808241 |
Mst1/2 is also activated by binding to Ras association domain family (RASSF) proteins, possibly owing to alteration of Mst1/2 subcellular localization. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Hippo Signaling |
+ |
STK3 | up-regulates
phosphorylation
|
LATS1/2 |
0.598 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-269862 |
|
|
Homo sapiens |
|
pmid |
sentence |
21808241 |
Activation of mst1/2 leads to phosphorylation and activation of their direct substrates, lats1/2. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Hippo Signaling |
+ |
TAOK | up-regulates
phosphorylation
|
STK3 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-230713 |
|
|
Homo sapiens |
|
pmid |
sentence |
23431053 |
In addition, the thousand-and-one (tao) amino acids kinase or taok13 has been shown to directly phosphorylate and activate hpo or mst1/2. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Hippo Signaling |
+ |
TAOK2 | up-regulates
phosphorylation
|
STK3 |
0.278 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-201327 |
|
|
Homo sapiens |
|
pmid |
sentence |
23431053 |
In addition, the thousand-and-one (tao) amino acids kinase or taok13 has been shown to directly phosphorylate and activate hpo or mst1/2. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
WWC1 | up-regulates activity
|
STK3 |
0.379 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-261953 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
20159598 |
These results shed light on the mechanism of Ex and Mer function and implicate Kibra as a potential tumor suppressor with relevance to neurofibromatosis. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Hippo Signaling |
+ |
SAV1 | up-regulates quantity by stabilization
binding
|
STK3 |
0.823 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-261957 |
|
|
Homo sapiens |
T-REx 293 Cell |
pmid |
sentence |
16930133 |
Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Hippo Signaling |
+ |
RASSF6 | down-regulates
binding
|
STK3 |
0.641 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-198463 |
|
|
Homo sapiens |
|
pmid |
sentence |
22830020 |
When rassf 6 is bound to mst2, rassf 6 inhibits mst2 activity, thus, inhibiting its role in the hippo pathway. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
TAOK3 | up-regulates
phosphorylation
|
STK3 |
0.295 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-201333 |
|
|
Homo sapiens |
|
pmid |
sentence |
23431053 |
In addition, the thousand-and-one (tao) amino acids kinase or taok1 3 has been shown to directly phosphorylate and activate hpo or mst1/2 |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
RAF1 | down-regulates
binding
|
STK3 |
0.365 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-132824 |
|
|
Homo sapiens |
|
pmid |
sentence |
15618521 |
Raf-1 prevents dimerization and phosphorylation of the activation loop of mst2 independently of its protein kinase activity.Raf-1 counteracts apoptosis by suppressing the activation of mammalian sterile 20-like kinase (mst2) |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
NF2 | up-regulates activity
binding
|
STK3 |
0.335 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-261955 |
|
|
Mus musculus |
Cardiomyocyte Cell Line |
pmid |
sentence |
27402866 |
NF2 is activated by oxidative stress in cardiomyocytes and mouse myocardium and facilitates apoptosis. NF2 promotes I/R injury through activation of Mst1 and inhibition of Yap, thereby regulating Hippo signaling in the adult heart. |
|
Publications: |
1 |
Organism: |
Mus Musculus |
Pathways: | Hippo Signaling |
+ |
RASSF1 | up-regulates activity
binding
|
STK3 |
0.681 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-249588 |
|
|
Homo sapiens |
|
pmid |
sentence |
22195963 |
Mutant K-Ras promotes MST2 activation in two ways (i.e., by direct disruption of the inhibitory Raf-1-MST2 complex (Matallanas et al., 2008) and by forming an activating K-Ras-RASSF1AMST2 complex, as reported here. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Hippo Signaling |
+ |
TAOK1 | up-regulates
phosphorylation
|
STK3 |
0.303 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-201321 |
|
|
Homo sapiens |
|
pmid |
sentence |
23431053 |
In addition, the thousand-and-one (tao) amino acids kinase or taok13 has been shown to directly phosphorylate and activate hpo or mst1/2. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |