Relation Results

Summary

Name ARHGAP30
Full Name Rho GTPase-activating protein 30
Synonyms Rho-type GTPase-activating protein 30 |
Primary ID Q7Z6I6
Links - -
Type protein
Relations 3
Function GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42.

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Type: Score: Layout: SPV 
0.3950.4420.452ARHGAP30RAC1RHOACDC42

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Relations
Regulator
Mechanism
target
score ℹ
+ ARHGAP30down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.395
Identifier Residue Sequence Organism Cell Line
SIGNOR-260486 Homo sapiens HEK-293 Cell
pmid sentence
We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity among regulators, but also that the inactivating RhoGAPs are less selective than the activating RhoGEFs (p-value=0.02)(Supplementary Table 2).
Publications: 1 Organism: Homo Sapiens
+ ARHGAP30down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.442
Identifier Residue Sequence Organism Cell Line
SIGNOR-260485 Homo sapiens
pmid sentence
We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity among regulators, but also that the inactivating RhoGAPs are less selective than the activating RhoGEFs (p-value=0.02)(Supplementary Table 2).
Publications: 1 Organism: Homo Sapiens
+ ARHGAP30down-regulates activity img/direct_inhibition.png gtpase-activating protein CDC42 0.452
Identifier Residue Sequence Organism Cell Line
SIGNOR-260487 Homo sapiens HEK-293 Cell
pmid sentence
We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity among regulators, but also that the inactivating RhoGAPs are less selective than the activating RhoGEFs (p-value=0.02)(Supplementary Table 2).
Publications: 1 Organism: Homo Sapiens
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