| + |
ARHGEF25 | up-regulates activity 
guanine nucleotide exchange factor
|
RHOA |
0.829 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260544 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32203420 |
We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity among regulators, but also that the inactivating RhoGAPs are less selective than the activating RhoGEFs (p-value=0.02)(Supplementary Table 2). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ARHGEF25 | up-regulates
guanine nucleotide exchange factor
|
RHOA |
0.829 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236885 |
|
|
Mus musculus |
C2C12 Cell, Myoblast |
| pmid |
sentence |
| 16314529 |
Exogenous expression of geft promotes myogenesis ofc2c12 cells via activation of rhoa, rac1, and cdc42 and their downstream effector proteins, while a dominant negative mutant of geft inhibits this process. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ARHGEF25 | up-regulates
guanine nucleotide exchange factor
|
CDC42 |
0.656 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235391 |
|
|
Mus musculus |
C2C12 Cell, Myoblast |
| pmid |
sentence |
| 16314529 |
Exogenous expression of geft promotes myogenesis of c2c12 cells via activation of rhoa, rac1, and cdc42 and their downstream effector proteins, while a dominant negative mutant of geft inhibits this process. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ARHGEF25 | up-regulates
guanine nucleotide exchange factor
|
RAC1 |
0.605 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236882 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16314529 |
Exogenous expression of geft promotes myogenesis ofc2c12 cells via activation of rhoa, rac1, and cdc42 and their downstream effector proteins, while a dominant negative mutant of geft inhibits this process. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
GNAQ | up-regulates activity
binding
|
ARHGEF25 |
0.571 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256493 |
|
|
in vitro |
|
| pmid |
sentence |
| 17606614 |
P63RhoGEF is autoinhibited by the Dbl homology (DH)-associated pleckstrin homology (PH) domain; activated Galpha(q) relieves this autoinhibition by interacting with a highly conserved C-terminal extension of the PH domain |
|
| Publications: |
1 |
Organism: |
In Vitro |
3.0
ARHGEF25
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