3.0
Summary
| Name |  TICAM2View Modifications |
| Full Name | TIR domain-containing adapter molecule 2 |
| Synonyms | TICAM-2, Putative NF-kappa-B-activating protein 502, TRIF-related adapter molecule, Toll-like receptor adaptor protein 3, Toll/interleukin-1 receptor domain-containing protein, MyD88-4 | TIRAP3, TIRP, TRAM |
| Primary ID | Q86XR7 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Pathways | Macrophage polarization, Toll like receptors |
| Function | Functions as sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction (PubMed:16603631, PubMed:16757566, PubMed:25385819, PubMed:25825441). In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement (PubMed:25385819). Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response (PubMed:22685567). Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria (PubMed:30883606). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKCE | up-regulates 
phosphorylation
|
TICAM2 | 0.591 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TICAM2 | up-regulates activity
binding
|
TICAM1 | 0.568 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Macrophage polarization, Toll like receptors | |||
| + | TLR9 | up-regulates activity
binding
|
TICAM2 | 0.411 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | TLR4 | up-regulates
binding
|
TICAM2 | 0.723 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Macrophage polarization | |||
| + | TLR2 | up-regulates activity
binding
|
TICAM2 | 0.44 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | TLRs | up-regulates activity
binding
|
TICAM2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Toll like receptors | |||