Summary

Name KSR1
Full Name Kinase suppressor of Ras 1
Synonyms KSR1_HUMAN | KSR
Primary ID Q8IVT5
Links - -
Type protein
Relations 8
Function Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation KSR1 0.565
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation KSR1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation KSR1 0.565
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RAF1 0.634
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding BRAF 0.608
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ARAF 0.544
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RAF1 0.634
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination KSR1 0.643
Publications: 1 Organism: Homo Sapiens