Summary

Name TAB3
Full Name TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
Synonyms Mitogen-activated protein kinase kinase kinase 7-interacting protein 3, NF-kappa-B-activating protein 1, TAK1-binding protein 3, TAB-3, TGF-beta-activated kinase 1-binding protein 3 | MAP3K7IP3
Primary ID Q8N5C8
Links - -
Type protein
Relations 6
Pathways NF-KB Canonical
Function Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor.

Viewer

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

Relations

Regulator Mechanism target score ℹ
+ TRAF6up-regulates activity img/direct-activation.png binding TAB3 0.702
Publications: 1 Organism: Homo Sapiens
Pathways:NF-KB Canonical
+ RIPK1up-regulates activity img/direct-activation.png binding TAB3 0.557
Publications: 1 Organism: Homo Sapiens
Pathways:NF-KB Canonical
+ TAB3up-regulates img/direct-activation.png binding JNK 0.373
Publications: 1 Organism: Homo Sapiens
+ TAB3up-regulates activity img/direct-activation.png binding MAP3K7 0.826
Publications: 1 Organism: Homo Sapiens
Pathways:NF-KB Canonical
+ TAB3up-regulates img/direct-activation.png binding p38 0.439
Publications: 1 Organism: Homo Sapiens
+ SMAD7up-regulates img/direct-activation.png binding TAB3 0.391
Publications: 1 Organism: Homo Sapiens