| + |
DCAF4 | down-regulates quantity by destabilization 
binding
|
ST7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272303 |
|
|
Homo sapiens |
Colonic Epithelial Cell |
| pmid |
sentence |
| 30945288 |
We found that both CUL4A and CUL4B can form an E3 complex with DNA damage-binding protein 1 (DDB1) and DDB1-CUL4-associated factor 4 (DCAF4). In vitro and in vivo ubiquitination analyses indicate that CRL4DCAF4 E3 ligase specifically directs degradation of ST7 (suppression of tumorigenicity 7). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DCAF4 | up-regulates activity 
binding
|
Cullin4-RBX1-DDB1 |
0.546 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272211 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 32014991 |
DCAF4-mediated ubiquitination of OPTN facilitates the degradation of DBR-exposed SOD1. OPTN is involved in degradation of DBR-exposed SOD1. These data demonstrate that DCAF4-including CRL4 complex mediates OPTN ubiquitination at lysine 501, and this ubiquitination is absent in the ALS-related OPTNmut. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272308 |
|
|
Homo sapiens |
Colonic Epithelial Cell |
| pmid |
sentence |
| 30945288 |
We found that both CUL4A and CUL4B can form an E3 complex with DNA damage-binding protein 1 (DDB1) and DDB1-CUL4-associated factor 4 (DCAF4). In vitro and in vivo ubiquitination analyses indicate that CRL4DCAF4 E3 ligase specifically directs degradation of ST7 (suppression of tumorigenicity 7). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
DCAF4 | up-regulates activity
binding
|
OPTN |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272210 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 32014991 |
DCAF4-mediated ubiquitination of OPTN facilitates the degradation of DBR-exposed SOD1. OPTN is involved in degradation of DBR-exposed SOD1. These data demonstrate that DCAF4-including CRL4 complex mediates OPTN ubiquitination at lysine 501, and this ubiquitination is absent in the ALS-related OPTNmut. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
DCAF4
- 
- 