| + |
DCAF4 | down-regulates quantity by destabilization 
binding
|
ST7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272303 |
|
|
Homo sapiens |
Colonic Epithelial Cell |
| pmid |
sentence |
| 30945288 |
We found that both CUL4A and CUL4B can form an E3 complex with DNA damage-binding protein 1 (DDB1) and DDB1-CUL4-associated factor 4 (DCAF4). In vitro and in vivo ubiquitination analyses indicate that CRL4DCAF4 E3 ligase specifically directs degradation of ST7 (suppression of tumorigenicity 7). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMARCA1 | down-regulates quantity by repression
transcriptional regulation
|
ST7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268991 |
|
|
|
|
| pmid |
sentence |
| 15485929 |
Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes. |
|
| Publications: |
1 |
| + |
Cullin4-RBX1-DDB1 | down-regulates quantity by destabilization
polyubiquitination
|
ST7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272309 |
|
|
Homo sapiens |
Colonic Epithelial Cell |
| pmid |
sentence |
| 30945288 |
We found that both CUL4A and CUL4B can form an E3 complex with DNA damage-binding protein 1 (DDB1) and DDB1-CUL4-associated factor 4 (DCAF4). In vitro and in vivo ubiquitination analyses indicate that CRL4DCAF4 E3 ligase specifically directs degradation of ST7 (suppression of tumorigenicity 7). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ST7
- 
- 