Summary

Name ARAP2
Full Name Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
Synonyms Centaurin-delta-1, Cnt-d1, Protein PARX | CENTD1, KIAA0580
Primary ID Q8WZ64
Links - -
Type protein
Relations 3
Function Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ ARAP2down-regulates activity img/direct_inhibition.png gtpase-activating protein CDC42 0.473
Publications: 1 Organism: Homo Sapiens
+ ARAP2down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.492
Publications: 1 Organism: Homo Sapiens
+ ARAP2down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.439
Publications: 1 Organism: Homo Sapiens