4.0
Summary
| Name |  RAD50View Modifications |
| Full Name | DNA repair protein RAD50 |
| Synonyms | hRAD50 |
| Primary ID | Q92878 |
| Links |  -  -  |
| Type | protein |
| Relations | 8 |
| Pathways | DNA repair in cancer |
| Function | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PubMed:11741547, PubMed:9590181, PubMed:9705271, PubMed:9651580). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ATM |
phosphorylation
|
RAD50 | 0.814 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | DNA repair in cancer | |||
| + | RBL2 | up-regulates activity 
binding
|
RAD50 | 0.302 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RAD50 | up-regulates
binding
|
ATM | 0.814 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| Pathways: | DNA repair in cancer | |||
| + | RAD50 | up-regulates
binding
|
BRCA1 | 0.788 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | DNA repair in cancer | |||
| + | RAD50 | up-regulates
binding
|
MRE11 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | DNA repair in cancer | |||
| + | RAD50 | form complex 
binding
|
MRE11/RAD50/NBS1 | 0.914 |
| Publications: | 1 | |||
| Pathways: | DNA repair in cancer | |||
| + | RAD50 | up-regulates activity
binding
|
RINT1 | 0.469 |
| Publications: | 1 | Organism: | Homo Sapiens | |