| + |
RAD50 | form complex 
binding
|
MRE11/RAD50/NBS1 |
0.91 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251506 |
|
|
|
|
| pmid |
sentence |
| 17713585 |
The mre11_rad50_nbs1 (mrn) complex is among the earliest respondents to dna double-strand breaks (dsbs). To organize the mrn complex, the mre11 exonuclease directly binds nbs1, dna, and rad50. |
|
| Publications: |
1 |
| Pathways: | DNA repair in cancer |
| + |
MRE11/RAD50/NBS1 | up-regulates 
|
Mitotic_checkpoint |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251503 |
|
|
|
|
| pmid |
sentence |
| 17713585 |
The mre11_rad50_nbs1 (mrn) complex is among the earliest respondents to dna double-strand breaks (dsbs).|Current emerging structural and biological evidence suggests that MRN has 3 coupled critical roles in DSB sensing, stabilization, signaling, and effector scaffolding: (1) expeditious establishment of protein--nucleic acid tethering scaffolds for the recognition and stabilization of DSBs; (2) initiation of DSB sensing, cell-cycle checkpoint signaling cascades, and establishment of epigenetic marks via the ATM kinase; and (3) functional regulation of chromatin remodeling in the vicinity of a DSB. |
|
| Publications: |
1 |
| Pathways: | Cell cycle: G2/M phase transition |
| + |
MRE11/RAD50/NBS1 | up-regulates
|
DNA_repair |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251502 |
|
|
|
|
| pmid |
sentence |
| 17713585 |
The mre11_rad50_nbs1 (mrn) complex is among the earliest respondents to dna double-strand breaks (dsbs).|Current emerging structural and biological evidence suggests that MRN has 3 coupled critical roles in DSB sensing, stabilization, signaling, and effector scaffolding: (1) expeditious establishment of protein--nucleic acid tethering scaffolds for the recognition and stabilization of DSBs; (2) initiation of DSB sensing, cell-cycle checkpoint signaling cascades, and establishment of epigenetic marks via the ATM kinase; and (3) functional regulation of chromatin remodeling in the vicinity of a DSB. |
|
| Publications: |
1 |
| Pathways: | DNA repair in cancer, Cell cycle: G2/M phase transition |
| + |
MRE11/RAD50/NBS1 | up-regulates activity 
relocalization
|
UFL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265074 |
|
|
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 30886146 |
UFM1 specific ligase 1 (UFL1), an ufmylation E3 ligase, is important for ATM activation. UFL1 is recruited to double strand breaks by the MRE11/RAD50/NBS1 complex, and monoufmylates histone H4 following DNA damage. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MRE11/RAD50/NBS1 | form complex
binding
|
BRCA1-C complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263221 |
|
|
|
|
| pmid |
sentence |
| 25400280 |
The BRCA1–C complex consisting of BRCA1, Mre11:Rad50:Nbs1 (collectively known as the MRN complex) and CtIP plays a role in DSB end resection, a process that also involves EXO1 and DNA2 |
|
| Publications: |
1 |
| + |
BRCA1 | up-regulates activity
binding
|
MRE11/RAD50/NBS1 |
0.765 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251501 |
|
|
|
|
| pmid |
sentence |
| 10426999 |
BRCA1 encodes a tumor suppressor that is mutated in familial breast and ovarian cancers. Here, it is shown that BRCA1 interacts in vitro and in vivo with hRad50, which forms a complex with hMre11 and p95/nibrin. Upon irradiation, BRCA1 was detected in discrete foci in the nucleus, which colocalize with hRad50.| These data suggest that BRCA1 is important for the cellular responses to DNA damage that are mediated by the hRad50-hMre11-p95 complex. |
|
| Publications: |
1 |
| Pathways: | DNA repair in cancer, Cell cycle: G2/M phase transition |
| + |
MRE11 | form complex
binding
|
MRE11/RAD50/NBS1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251504 |
|
|
|
|
| pmid |
sentence |
| 17713585 |
The mre11_rad50_nbs1 (mrn) complex is among the earliest respondents to dna double-strand breaks (dsbs). To organize the mrn complex, the mre11 exonuclease directly binds nbs1, dna, and rad50. |
|
| Publications: |
1 |
| Pathways: | DNA repair in cancer |
| + |
NBN | form complex
binding
|
MRE11/RAD50/NBS1 |
0.91 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251505 |
|
|
|
|
| pmid |
sentence |
| 17713585 |
The mre11_rad50_nbs1 (mrn) complex is among the earliest respondents to dna double-strand breaks (dsbs). To organize the mrn complex, the mre11 exonuclease directly binds nbs1, dna, and rad50. |
|
| Publications: |
1 |
3.0
MRE11/RAD50/NBS1
CPX-4442