Summary

Name KAT5
Full Name Histone acetyltransferase KAT5
Synonyms 60 kDa Tat-interactive protein, Tip60, Histone acetyltransferase HTATIP, HIV-1 Tat interactive protein, Lysine acetyltransferase 5, cPLA(2)-interacting protein | HTATIP, TIP60
Primary ID Q92993
Links - -
Type protein
Relations 17
Pathways Acute Myeloid Leukemia, IDH-TET in AML
Function Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:12776177, PubMed:15042092, PubMed:15121871, PubMed:15310756, PubMed:14966270, PubMed:16387653, PubMed:19909775, PubMed:15196461). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:12776177, PubMed:15042092, PubMed:15121871, PubMed:15310756, PubMed:14966270, PubMed:15196461). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:15196461). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (PubMed:15196461). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Also acetylates non-histone proteins, such as ATM, NR1D2, RAN, FOXP3, ULK1 and RUBCNL/Pacer (PubMed:16141325, PubMed:17360565, PubMed:17996965, PubMed:29040603, PubMed:30704899). Directly acetylates and activates ATM (PubMed:16141325). Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2 (PubMed:17996965). Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity (PubMed:17360565). Acetylates RAN at 'Lys-134' (PubMed:29040603). Together with GSK3 (GSK3A or GSK3B), acts as a regulator of autophagy

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ KAT5down-regulates img/direct_inhibition.png acetylation NOTCH1 0.424
Publications: 4 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ KAT5down-regulates activity img/direct_inhibition.png acetylation H4C1 0.2
Publications: 1 Organism: Homo Sapiens
+ KAT5up-regulates activity img/direct-activation.png acetylation CHKA 0.2
Publications: 1 Organism: Homo Sapiens
+ KAT5up-regulates activity img/direct-activation.png acetylation ATM 0.794
Publications: 1
+ KAT5down-regulates img/direct_inhibition.png acetylation SRSF2 0.48
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, IDH-TET in AML
+ CyclinB/CDK1up-regulates activity img/direct-activation.png phosphorylation KAT5 0.428
Publications: 2 Organism: Homo Sapiens
+ GSK3Bup-regulates img/direct-activation.png phosphorylation KAT5 0.376
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ CDK1up-regulates img/direct-activation.png phosphorylation KAT5 0.491
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, IDH-TET in AML
+ ABL1down-regulates activity img/direct_inhibition.png phosphorylation KAT5 0.633
Publications: 1 Organism: Homo Sapiens
+ KAT5form complex img/form-complex.png binding NuA4 complex 0.775
Publications: 1 Organism: Homo Sapiens
+ KAT5up-regulates activity img/direct-activation.png binding MYOD1 0.372
Publications: 1 Organism: Homo Sapiens
+ MDM2down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination KAT5 0.639
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, IDH-TET in AML