| + |
ALS2 | up-regulates activity 
binding
|
RAB5A |
0.725 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277776 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 30485418 |
ALS2 activates Rab5 on macropinosomes. Rab5 is activated and concurrently recruited to macropinosomes during ruffle closure. ALS2 depletion abolishes transient Rab5 activation on macropinosomes, while ALS2 is recruited to macropinosomes simultaneously with Rab5 activation. Thus, we conclude ALS2 activates Rab5 on macropinosomes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAC1 | up-regulates activity
binding
|
ALS2 |
0.515 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277777 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 30485418 |
Thus, in our system, activeRac1 may recruit ALS2 only at the very early stage ofmacropinocytosis including membrane ruffles, suggest-ing that ALS2 is retained by some other mechanismsuntil Rab conversion. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAB7A | down-regulates activity 
binding
|
ALS2 |
0.311 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277778 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 30485418 |
The absence of active Rab7 prolongs ALS2presence and Rab5 activation on macropinosomes, indicating that activeRab7 is necessary for Rab5 inactivation through ALS2 dissociation and playskey roles in the Rab switch on macropinosomes. Taken together, active Rab7is necessary for Rab5 down-regulation through ALS2dissociation, thereby acting as a central component inthe Rab5-to-Rab7 switch in macropinocytosis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ALS2
- 
- 