4.0
Summary
| Name |  TP53RKView Modifications |
| Full Name | EKC/KEOPS complex subunit TP53RK |
| Synonyms | Atypical serine/threonine protein kinase TP53RK, EKC/KEOPS complex subunit TP53RK, 3.6.-.-, Nori-2, p53-related protein kinase | C20orf64, PRPK |
| Primary ID | Q96S44 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914). TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | TP53RK | up-regulates 
phosphorylation
|
TP53 | 0.761 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PBK | up-regulates activity
phosphorylation
|
TP53RK | 0.42 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AKT | up-regulates
phosphorylation
|
TP53RK | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AKT1 | up-regulates
phosphorylation
|
TP53RK | 0.297 |
| Publications: | 1 | Organism: | Homo Sapiens | |