Summary

Name MAP3K14
Full Name Mitogen-activated protein kinase kinase kinase 14
Synonyms NF-kappa-beta-inducing kinase, HsNIK, Serine/threonine-protein kinase NIK | NIK
Primary ID Q99558
Links - -
Type protein
Relations 20
Pathways Innate Immune Response, NF-KB Non Canonical
Function Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation CHUK 0.678
Publications: 3 Organism: Homo Sapiens
Pathways:NF-KB Non Canonical
+ up-regulates activity img/direct-activation.png phosphorylation NFKB2 0.662
Publications: 2 Organism: Homo Sapiens
Pathways:NF-KB Non Canonical
+ up-regulates activity img/direct-activation.png phosphorylation MAP3K14 0.534
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation MAP3K14 0.678
Publications: 1 Organism: Homo Sapiens
Pathways:NF-KB Non Canonical
+ up-regulates activity img/direct-activation.png binding MAP3K14 0.615
Publications: 1 Organism: Homo Sapiens
Pathways:Innate Immune Response
+ up-regulates activity img/direct-activation.png phosphorylation MAP3K14 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Innate Immune Response, NF-KB Non Canonical
+ up-regulates activity img/direct-activation.png binding MAP3K14 0.5
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding MAP3K14 0.652
Publications: 1 Organism: Mus Musculus
Pathways:Innate Immune Response, NF-KB Non Canonical
+ up-regulates activity img/direct-activation.png binding MAP3K14 0.564
Publications: 1 Organism: Homo Sapiens
Pathways:NF-KB Non Canonical
+ up-regulates img/direct-activation.png ubiquitination MAP3K14 0.519
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png NfKb-p65/p50 0.363
Publications: 1 Organism: Homo Sapiens
Pathways:Innate Immune Response
+ up-regulates img/direct-activation.png phosphorylation IKK-complex 0.707
Publications: 1 Organism: Homo Sapiens
Pathways:Innate Immune Response, NF-KB Non Canonical
+ down-regulates img/direct_inhibition.png ubiquitination MAP3K14 0.632
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination, binding MAP3K14 0.564
Publications: 2 Organism: Homo Sapiens, Mus Musculus
Pathways:NF-KB Non Canonical
+ up-regulates activity img/direct-activation.png phosphorylation MAP3K14 0.539
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation IKBKB 0.695
Publications: 1 Organism: Homo Sapiens