| + |
MAP3K14 | up-regulates activity 
phosphorylation
|
CHUK |
0.697 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-55942 |
Ser176 |
AKDVDQGsLCTSFVG |
Homo sapiens |
|
| pmid |
sentence |
| 9520446 |
Nf-kappab-inducing kinase activates ikk-alpha by phosphorylation of ser-176. Nik preferentially phosphorylates ikk-alpha over ikk-beta, leading to the activation of ikk-alpha kinase activity; the accumulated nik phosphorylates ikkalfa. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-55946 |
Ser180 |
DQGSLCTsFVGTLQY |
Homo sapiens |
|
| pmid |
sentence |
| 9520446 |
NIK preferentially phosphorylates ikk-alpha over ikk-beta, leading to the activation of ikk-alpha kinase activity; the accumulated nik phosphorylates ikkalfa. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167060 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20651737 |
Once activated by autophosphorylation, nik activates ikkalpha, which in turn phosphorylates nf-kb2. This stimulates limited proteasome-mediated proteolysis of nf-kb2 to p52. Removal of the carboxy-terminal ankyrin repeats from nf-kb2 releases the p52/RELB heterodimer, allowing its translocation to the nucleus where it instigates the expression of nf-kb target genes. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | NF-KB Non Canonical |
| + |
MAP3K14 | up-regulates activity
phosphorylation
|
G6PD |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277545 |
Ser40 |
IFIIMGAsGDLAKKK |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 33398181 |
Mass spectrometry identified four serine residues of G6PD phosphorylated by NIK (Extended Data Fig. 8f). All of these serines, except S278, are conserved between human and mouse G6PD proteins. In transfected cells, NIK stimulated G6PD activity, which was not affected by S8A or S486A mutation but abolished by S40A mutation (Extended Data Fig. 8g). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K14 | up-regulates activity
phosphorylation
|
STAT3 |
0.26 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279340 |
Ser727 |
NTIDLPMsPRTLDSL |
Homo sapiens |
|
| pmid |
sentence |
| 17543278 |
Activation of Stat3 by NIK requires NIK kinase activity as showed by kinase assays.|When we transfected NIK into LNCaP cells, NIK was able to phosphorylate Stat3 at both tyrosine 705 and serine 727 residues. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279341 |
Tyr705 |
DPGSAAPyLKTKFIC |
Homo sapiens |
|
| pmid |
sentence |
| 17543278 |
Activation of Stat3 by NIK requires NIK kinase activity as showed by kinase assays.|When we transfected NIK into LNCaP cells, NIK was able to phosphorylate Stat3 at both tyrosine 705 and serine 727 residues ( Fig. 3 A). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAP3K14 | up-regulates activity
phosphorylation
|
NFKB2 |
0.679 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105553 |
Ser866 |
TAEVKEDsAYGSQSV |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11239468 |
NIK-induced p100 processing requires phosphorylation of p100 at serines 866 and 870 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105557 |
Ser870 |
KEDSAYGsQSVEQEA |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11239468 |
NIK-induced p100 processing requires phosphorylation of p100 at serines 866 and 870 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | NF-KB Non Canonical |
| + |
MAP3K8 | up-regulates activity
phosphorylation
|
MAP3K14 |
0.559 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249387 |
Thr559 |
TGDYIPGtETHMAPE |
Homo sapiens |
|
| pmid |
sentence |
| 9742107 |
In studies of NIK, we found that Thr-559 located within the activation loop of its kinase domain regulates NIK action. Alanine substitution of Thr-559 but not other serine or threonine residues within the activation loop abolishes its activity and its ability to phosphorylate and activate IKKalpha |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHUK | down-regulates quantity by destabilization 
phosphorylation
|
MAP3K14 |
0.697 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165622 |
Thr559 |
TGDYIPGtETHMAPE |
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 20501937 |
Upon activation by nik, ikkalfa phosphorylates nik, triggering its proteolysis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | NF-KB Non Canonical |
| + |
TRAPPC9 | up-regulates activity
binding
|
MAP3K14 |
0.48 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269672 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 15951441 |
We demonstrated by immunohistochemistry that NIBP expression in the brain is localized to neurons. NIBP physically interacts with NIK, IKK(beta), but not IKK(alpha) or IKK(gamma). NIBP overexpression potentiates tumor necrosis factor-alpha-induced NF-kappaB activation through increased phosphorylation of the IKK complex and its downstream I(kappa)B(alpha) and p65 substrates. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K14 | up-regulates activity
phosphorylation
|
SLC9A1 |
0.305 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279632 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11369779 |
The Nck-interacting kinase (NIK) phosphorylates the Na+-H+ exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor.|We now show that NIK binds to and divergently activates the plasma membrane Na(+)-H(+) exchanger NHE1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TRAF3 | down-regulates quantity by destabilization
binding, ubiquitination
|
MAP3K14 |
0.669 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124236 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15084608 |
Traf3 is physically associated with nik via a specific sequence motif located in the n-terminal region of nik; this molecular interaction appears to target nik for degradation by the proteasome. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278673 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26085207 |
TRAF2 and TRAF3 mediate NIK ubiquitination by forming a complex with the E3 ligase cIAP (cIAP1 or cIAP2).|We demonstrated further that TRAF3 mediates the degradation of NIK and thereby serves as a pivotal negative regulator of noncanonical NF-kappaB signaling. |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Homo Sapiens |
| Pathways: | Innate Immune Response, NF-KB Non Canonical |
| + |
MAP3K7 | up-regulates activity
phosphorylation
|
MAP3K14 |
0.564 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262833 |
|
|
|
|
| pmid |
sentence |
| 10094049 |
The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway|Activated TAK1 phosphorylates NIK, which stimulates IKK-alpha activity. Our results indicate that TAK1 links TRAF6 to the NIK-IKK cascade in the IL-1 signalling pathway. |
|
| Publications: |
1 |
| + |
MAP3K14 | up-regulates activity
phosphorylation
|
MAP3K14 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167063 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20651737 |
As nik levels increase, nik presumably becomes activated by autophosphorylation (p). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Innate Immune Response, NF-KB Non Canonical |
| + |
TRAF2 | up-regulates activity
binding
|
MAP3K14 |
0.587 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-46215 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9020361 |
NIK binds to Traf2 and stimulates NF-kappaB activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | NF-KB Non Canonical |
| + |
TRAF2 | down-regulates quantity by destabilization
binding, ubiquitination
|
MAP3K14 |
0.587 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124233 |
|
|
Mus musculus |
Lymphoma Cell |
| pmid |
sentence |
| 15084608 |
We report here that one important mechanism of nik regulation is through its dynamic interaction with the tumor necrosis factor receptor-associated factor 3 (traf3). Traf3 physically associates with nik via a specific sequence motif located in the n-terminal region of nik; this molecular interaction appears to target nik for degradation by the proteasome. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167066 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20651737 |
Under resting conditions cellular inhibitor of apoptosis (ciap) proteins target nuclear factor-kb (nf-kb)-inducing kinase (nik) for ubiquitylation and proteasomal degradation. |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Homo Sapiens |
| Pathways: | NF-KB Non Canonical |
| + |
TRAF6 | up-regulates activity
binding
|
MAP3K14 |
0.631 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253048 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10075662 |
RANK activates NF-κB by interacting with TRAF6 via a novel TRAF6 interaction motif and TRAF6 potentially activates NIK, leading to NF-κB activation. TRAF6 has been demonstrated to interact with NIK. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Innate Immune Response |
| + |
MAP3K14 | up-regulates activity
phosphorylation
|
MMP14 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279631 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27270613 |
A post-transcriptional process is indicated because we observed that NIK increases MT1-MMP phosphorylation and activity, but does not affect MT1-MMP mRNA expression (XREF_FIG and XREF_FIG).|NIK increases MT1-MMP pseudopodial localization and enzymatic activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZFP91 | up-regulates
ubiquitination
|
MAP3K14 |
0.5 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167331 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20682767 |
Zfp91 interacts with and promotes the lys(63)-linked ubiquitination of nik and subsequent processing of p100 to p52. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K14 | up-regulates
phosphorylation
|
IKK-complex |
0.724 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217433 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9520446 |
Nf-kappab-inducing kinase activates ikk-alpha by phosphorylation of ser-176.Nik preferentially phosphorylates ikk-alpha over ikk-beta, leading to the activation of ikk-alpha kinase activity; the accumulated nik phosphorylates ikkalfa. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Innate Immune Response, NF-KB Non Canonical |
| + |
BIRC3 | down-regulates
ubiquitination
|
MAP3K14 |
0.651 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167298 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20682767 |
Ciap1/2 (cellular inhibitor of apoptosis 1 and 2) ubiquitinate nik for degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TBK1 | down-regulates quantity by destabilization
phosphorylation
|
MAP3K14 |
0.368 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279767 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23023393 |
TBK1 induces NIK phosphorylation and degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Innate Immune Response |
| + |
MAP3K14 | up-regulates
phosphorylation
|
IKBKB |
0.713 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-55949 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9520446 |
Activation of the transcription factor nf-kappab by inflammatory cytokines involves the successive action of nf-kappab-inducing kinase (nik) and two ikappab kinases, ikk-alpha and ikk-beta. Here we show that nik preferentially phosphorylates ikk-alpha over ikk-beta |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K14 | up-regulates 
|
NfKb-p65/p50 |
0.352 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-46212 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9020361 |
Nik stimulates nf-kappab activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Innate Immune Response |
4.0
MAP3K14
- 
- 