4.0
Summary
| Name |  RAMACView Modifications |
| Full Name | RNA guanine-N7 methyltransferase activating subunit |
| Synonyms | Protein FAM103A1, RNA guanine-7 methyltransferase activating subunit, RNMT-activating mRNA cap methyltransferase subunit, RNMT-activating mini protein, RAM | C15orf18, FAM103A1, RAMMET |
| Primary ID | Q9BTL3 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Pathways | mRNA maturation |
| Function | Regulatory subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:22099306, PubMed:27422871). Promotes the recruitment of the methyl donor, S-adenosyl-L-methionine, to RNMT (PubMed:27422871). Regulates RNMT expression by a post-transcriptional stabilizing mechanism (PubMed:22099306). Binds RNA (PubMed:22099306). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ERK1/2 | down-regulates quantity by destabilization 
phosphorylation
|
RAMAC | 0.2 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | RAMAC | up-regulates activity 
binding
|
RNMT | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | mRNA maturation, mRNA maturation | |||