| + |
DNA_damage | up-regulates 
|
Fanconi anemia core complex |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263251 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 17396147 |
The Fanconi anemia (FA) core complex plays a central role in the DNA damage response network involving breast cancer susceptibility gene products, BRCA1 and BRCA2. The complex consists of eight FA proteins, including a ubiquitin ligase (FANCL) and a DNA translocase (FANCM), and is essential for monoubiquitination of FANCD2 in response to DNA damage. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Fanconi anemia core complex | up-regulates activity 
ubiquitination
|
FANCD2 |
0.783 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263249 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17396147 |
Thus, eight of the nine components of the FA core complex are FA proteins (FANC‐A, B, C, E, F, G, L, and M). Furthermore, two of the newly discovered FA proteins have enzymatic activities: FANCL is a ubiquitin ligase essential for FANCD2 monoubiquitination in vivo |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263265 |
|
|
|
|
| pmid |
sentence |
| 18985065 |
Phosphorylation of FANCD2 and Fanconi anemia core components (broken pink circles) affects the efficiency of, but is not essential for, ID ubiquitination by the FA core complex, together with E1 and UBE2T. Analogously, ubiquitination of FANCD2 (solid orange ovals) is essential for DNA repair, activating the ID complex for chromatin binding |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, |
| + |
Fanconi anemia core complex | up-regulates activity
ubiquitination
|
FANCI |
0.717 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263267 |
|
|
|
|
| pmid |
sentence |
| 18985065 |
Phosphorylation of FANCD2 and Fanconi anemia core components (broken pink circles) affects the efficiency of, but is not essential for, ID ubiquitination by the FA core complex, together with E1 and UBE2T. Analogously, ubiquitination of FANCD2 (solid orange ovals) is essential for DNA repair, activating the ID complex for chromatin binding |
|
| Publications: |
1 |
| + |
FANCB | form complex 
binding
|
Fanconi anemia core complex |
0.852 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263241 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 17396147 |
This complex includes not only the five known FA proteins (FANC‐A, C, E, F, and G), but also four new polypeptides, which are named FAAPs for FANCA‐associated polypeptides. |Thus, eight of the nine components of the FA core complex are FA proteins (FANC‐A, B, C, E, F, G, L, and M). Furthermore, two of the newly discovered FA proteins have enzymatic activities: FANCL is a ubiquitin ligase essential for FANCD2 monoubiquitination in vivo |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FAAP24 | form complex
binding
|
Fanconi anemia core complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263239 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 17396147 |
This complex includes not only the five known FA proteins (FANC‐A, C, E, F, and G), but also four new polypeptides, which are named FAAPs for FANCA‐associated polypeptides. |Thus, eight of the nine components of the FA core complex are FA proteins (FANC‐A, B, C, E, F, G, L, and M). Furthermore, two of the newly discovered FA proteins have enzymatic activities: FANCL is a ubiquitin ligase essential for FANCD2 monoubiquitination in vivo |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FANCE | form complex
binding
|
Fanconi anemia core complex |
0.849 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263247 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 17396147 |
This complex includes not only the five known FA proteins (FANC‐A, C, E, F, and G), but also four new polypeptides, which are named FAAPs for FANCA‐associated polypeptides. |Thus, eight of the nine components of the FA core complex are FA proteins (FANC‐A, B, C, E, F, G, L, and M). Furthermore, two of the newly discovered FA proteins have enzymatic activities: FANCL is a ubiquitin ligase essential for FANCD2 monoubiquitination in vivo |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FANCC | form complex
binding
|
Fanconi anemia core complex |
0.926 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263246 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 17396147 |
This complex includes not only the five known FA proteins (FANC‐A, C, E, F, and G), but also four new polypeptides, which are named FAAPs for FANCA‐associated polypeptides. |Thus, eight of the nine components of the FA core complex are FA proteins (FANC‐A, B, C, E, F, G, L, and M). Furthermore, two of the newly discovered FA proteins have enzymatic activities: FANCL is a ubiquitin ligase essential for FANCD2 monoubiquitination in vivo |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FANCA | form complex
binding
|
Fanconi anemia core complex |
0.953 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263240 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 17396147 |
This complex includes not only the five known FA proteins (FANC‐A, C, E, F, and G), but also four new polypeptides, which are named FAAPs for FANCA‐associated polypeptides. |Thus, eight of the nine components of the FA core complex are FA proteins (FANC‐A, B, C, E, F, G, L, and M). Furthermore, two of the newly discovered FA proteins have enzymatic activities: FANCL is a ubiquitin ligase essential for FANCD2 monoubiquitination in vivo |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FANCF | form complex
binding
|
Fanconi anemia core complex |
0.912 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263242 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 17396147 |
This complex includes not only the five known FA proteins (FANC‐A, C, E, F, and G), but also four new polypeptides, which are named FAAPs for FANCA‐associated polypeptides. |Thus, eight of the nine components of the FA core complex are FA proteins (FANC‐A, B, C, E, F, G, L, and M). Furthermore, two of the newly discovered FA proteins have enzymatic activities: FANCL is a ubiquitin ligase essential for FANCD2 monoubiquitination in vivo |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FANCL | form complex
binding
|
Fanconi anemia core complex |
0.913 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263245 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 17396147 |
This complex includes not only the five known FA proteins (FANC‐A, C, E, F, and G), but also four new polypeptides, which are named FAAPs for FANCA‐associated polypeptides. |Thus, eight of the nine components of the FA core complex are FA proteins (FANC‐A, B, C, E, F, G, L, and M). Furthermore, two of the newly discovered FA proteins have enzymatic activities: FANCL is a ubiquitin ligase essential for FANCD2 monoubiquitination in vivo |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FAAP100 | form complex
binding
|
Fanconi anemia core complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263244 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 17396147 |
This complex includes not only the five known FA proteins (FANC‐A, C, E, F, and G), but also four new polypeptides, which are named FAAPs for FANCA‐associated polypeptides. |Thus, eight of the nine components of the FA core complex are FA proteins (FANC‐A, B, C, E, F, G, L, and M). Furthermore, two of the newly discovered FA proteins have enzymatic activities: FANCL is a ubiquitin ligase essential for FANCD2 monoubiquitination in vivo |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FANCG | form complex
binding
|
Fanconi anemia core complex |
0.927 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263243 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 17396147 |
This complex includes not only the five known FA proteins (FANC‐A, C, E, F, and G), but also four new polypeptides, which are named FAAPs for FANCA‐associated polypeptides. |Thus, eight of the nine components of the FA core complex are FA proteins (FANC‐A, B, C, E, F, G, L, and M). Furthermore, two of the newly discovered FA proteins have enzymatic activities: FANCL is a ubiquitin ligase essential for FANCD2 monoubiquitination in vivo |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FANCM | form complex
binding
|
Fanconi anemia core complex |
0.937 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263248 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 17396147 |
This complex includes not only the five known FA proteins (FANC‐A, C, E, F, and G), but also four new polypeptides, which are named FAAPs for FANCA‐associated polypeptides. |Thus, eight of the nine components of the FA core complex are FA proteins (FANC‐A, B, C, E, F, G, L, and M). Furthermore, two of the newly discovered FA proteins have enzymatic activities: FANCL is a ubiquitin ligase essential for FANCD2 monoubiquitination in vivo |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
Fanconi anemia core complex
CPX-6263