| + |
ADNP | up-regulates quantity by stabilization 
binding
|
CTNNB1 |
0.254 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266756 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 32533114 |
Here, we show that ADNP is required for neural induction and differentiation by enhancing Wnt signaling. Mechanistically, ADNP functions to stabilize β-Catenin through binding to its armadillo domain which prevents its association with key components of the degradation complex: Axin and APC. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ADNP | up-regulates 
|
Neurogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266758 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 12888219 |
Mouse ADNP was shown to be expressed at the time of neural tube closure, detected at E7.5 and increased on E9.5. Expression was augmented in the brain (E12.5), sustained throughout embryogenesis and regulated by VIP. In conclusion, ADNP is identified here as a new key gene essential for organogenesis in the developing embryo and may be implicated as a clinical target associated with proper neurodevelopment. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ADNP | down-regulates activity 
relocalization
|
CTCF |
0.206 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266755 |
|
|
Mus musculus |
Embryonic Stem Cell |
| pmid |
sentence |
| 31491387 |
These results argue against the simultaneous binding of CTCF and ADNP to the same genomic loci. Instead, they support a model in which ADNP counteracts stable association of CTCF with DNA at over 15,000 binding sites in the mouse genome. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ADNP | up-regulates activity
binding
|
MAP1LC3B |
0.382 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266759 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 24365867 |
Here, we show for the first time that hippocampal ADNP deficiency paralleled reduced beclin1 expression which, in turn, parallels increased tauopathy and cell death. We now show that ADNP directly interacts with LC3B, implicating the requirement of a healthy ADNP system for the apoptotic/autophagy processes. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Tissue: |
Hippocampus |
| + |
ADNP | up-regulates quantity by expression
transcriptional regulation
|
BECN1 |
0.254 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266760 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 24365867 |
Here, we show for the first time that hippocampal ADNP deficiency paralleled reduced beclin1 expression which, in turn, parallels increased tauopathy and cell death. We now show that ADNP directly interacts with LC3B, implicating the requirement of a healthy ADNP system for the apoptotic/autophagy processes. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
ADNP | up-regulates quantity
binding
|
SWI/SNF complex |
0.364 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266757 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17878164 |
ADNP Co-precipitates with the SWI/SNF Complex through ADNP C-terminal Interaction. Down-regulation of ADNP by shRNA resulted in morphological changes that are in line with the fact that ADNP contains a homeodomain profile (2) and with the SWI/SNF complex function that is associated with cellular differentiation. Our results suggest that ADNP functionality plays a role in these changes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ADNP | form complex 
binding
|
ChAHP |
0.3 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266751 |
|
|
Mus musculus |
HM-1 ES Cell |
| pmid |
sentence |
| 29795351 |
Here we show that ADNP interacts with the chromatin remodeller CHD4 and the chromatin architectural protein HP1 to form a stable complex, which we refer to as ChAHP. Besides mediating complex assembly, ADNP recognizes DNA motifs that specify binding of ChAHP to euchromatin. we have discovered ChAHP, a gene-regulatory complex that consists of the chromatin remodeller CHD4, the DNA-binding factor ADNP, and the heterochromatin proteins HP1β and HP1γ. By locally restricting access to DNA, ChAHP prevents endodermal gene transcription in mouse ES cells and during neuroectodermal differentiation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
ADNP
- 
- 