3.0
Summary
| Name |  FOXA2View Modifications |
| Full Name | Hepatocyte nuclear factor 3-beta |
| Synonyms | HNF-3-beta, HNF-3B, Forkhead box protein A2, Transcription factor 3B, TCF-3B | HNF3B, TCF3B |
| Primary ID | Q9Y261 |
| Links |  -  -  |
| Type | protein |
| Relations | 11 |
| Pathways | FAP: In vitro induction of adipogenesis, FAP: Insulin-mediated adipogenesis, FAP: INSR, Pericyte: In vitro induction of adipogenesis |
| Function | Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CHUK | down-regulates 
phosphorylation
|
FOXA2 | 0.2 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | AKT | down-regulates activity
phosphorylation
|
FOXA2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | FAP: Insulin-mediated adipogenesis | |||
| + | POU5F1 | down-regulates quantity by repression 
transcriptional regulation
|
FOXA2 | 0.445 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FOXA2 | down-regulates quantity by repression
transcriptional regulation
|
SLCO1B3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CTNNB1 | up-regulates quantity by expression 
transcriptional regulation
|
FOXA2 | 0.462 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FOXA2 | up-regulates quantity by expression
transcriptional regulation
|
AHSG | 0.237 |
| Publications: | 1 | |||
| + | FOXA2 | up-regulates quantity by expression 
transcriptional regulation
|
DLK1 | 0.343 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Pathways: | FAP: Insulin-mediated adipogenesis | |||
| + | FOXA2 | down-regulates activity
binding
|
OTX2 | 0.572 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AKT | down-regulates
phosphorylation
|
FOXA2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | FAP: Insulin-mediated adipogenesis | |||
| + | NANOG | down-regulates quantity by repression
transcriptional regulation
|
FOXA2 | 0.473 |
| Publications: | 1 | Organism: | Homo Sapiens | |