| + |
KIF1C | up-regulates quantity 
relocalization
|
RAB6B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266878 |
|
|
in vitro |
|
| pmid |
sentence |
| 20360680 |
Here, we identify Bicaudal-D-related protein 1 (BICDR-1) as an effector of the small GTPase Rab6 and key component of the molecular machinery that controls secretory vesicle transport in developing neurons. BICDR-1 interacts with kinesin motor Kif1C, the dynein/dynactin retrograde motor complex, regulates the pericentrosomal localization of Rab6-positive secretory vesicles and is required for neural development in zebrafish. In young neurons, BICDR-1 accumulates Rab6 secretory vesicles around the centrosome, restricts anterograde secretory transport and inhibits neuritogenesis. Later during development, BICDR-1 expression is strongly reduced, which permits anterograde secretory transport required for neurite outgrowth. These results indicate an important role for BICDR-1 as temporal regulator of secretory trafficking during the early phase of neuronal differentiation. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
RAB6B | down-regulates activity 
binding
|
VPS13B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269205 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 25492866 |
Cohen syndrome-associated protein COH1 physically and functionally interacts with the small GTPase RAB6 at the Golgi complex and directs neurite outgrowth. COH1 Golgi Localization Is Mediated by Active RAB6 . COH1 Interacts with All Three Mammalian RAB6 Homologues |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAB6B | up-regulates 
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266874 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 25492866 |
Cohen syndrome-associated protein COH1 physically and functionally interacts with the small GTPase RAB6 at the Golgi complex and directs neurite outgrowth. COH1 and RAB6 regulate neurite outgrowth in primary neurons |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
RAB6B | up-regulates
|
Synaptic_vesicle_exocytosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266881 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 20360680 |
We show that BICDR-1 interacts with the dynein/dynactin motor complex, binds to kinesin-3 motor protein Kif1C and controls the pericentrosomal localization of Rab6-positive secretory vesicles. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
RAB6B | up-regulates activity
binding
|
VPS13B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266870 |
|
|
Rattus norvegicus |
Pyramidal Neuron |
| pmid |
sentence |
| 25492866 |
Cohen syndrome-associated protein COH1 physically and functionally interacts with the small GTPase RAB6 at the Golgi complex and directs neurite outgrowth. We show that COH1 forms a physical and functional complex with RAB6. Our results point to a role of COH1 as a RAB6 effector protein. Depletion of COH1 leads to decreased neurite outgrowth in cultured primary hippocampal neurons. These results establish a critical role for RAB6-dependent function of COH1 in neuritogenesis by regulating Golgi complex organization. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
3.0
RAB6B
- 
- 